miRBase entry: hsa-mir-431

Stem-loop hsa-mir-431

Homo sapiens hsa-mir-431 precursor miRNA
Gene family
MIPF0000142; mir-431

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR431 has been identified as a useful marker for monitoring sensorineural hearing loss (SNHL) and mitochondrial degeneration in both peripheral and central cells [PMC5822652]. In a study on mouse brain endothelial cells, MIR431 was found to be significantly elevated in response to HHcy [PMC6651274]. MIR431 is located in the DLK1-DIO3 locus at the 14q32 region, along with other flanking genes [PMC6202974]. Dual luciferase reporter assays have shown that MIR431 can down-regulate Lhx8 expression [PMC6716883]. MIR431 has been associated with character and targets a large number of genes [PMC7515844]. In male embryos, MIR431 is more severely affected upon loss of Zfp57 compared to female embryos [PMC8895500]. In various studies, MIR431 has been found to be both upregulated and downregulated in different contexts, such as exercise and Alzheimer's disease (AD) [PMC6482346] [PMC7564652]. Zhang et al. demonstrated that MIR431 can silence DAB2 interacting protein, promoting metastasis of pancreatic neuroendocrine tumors [PMC9218734]. Additionally, MIR431 has been identified as one of the miRNAs highly expressed in BMSC-derived exosomes associated with remyelination and axonal regeneration processes [PMC9069372]. Furthermore, DNA hypermethylation has been shown to silence several microRNAs encoded in the DLK1-MEG3 cluster at 14q32 region including MIR431 in bladder tumor tissues and cell lines [PMC4348104]..\

Literature search
28 open access papers mention hsa-mir-431
(46 sentences)


2041 reads, 54 reads per million, 55 experiments

---------------ucc  c     c       U          C  U A     ----   aca 
                  ug uuguc ugcgagg GUCUUGCAGG CG C UGCAg    gcc   c
                  || ||||| ||||||| |||||||||| || | |||||    |||    
                  ac agcag acgcUCU CGGGACGUUC GC G ACguu    ugg   u
gcagcaaccacuacuccu  -     a       U          U  U G     gcaa   cag 

Annotation confidence Not enough data
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Genome context
chr14: 100881007-100881120 [+]
Clustered miRNAs
6 other miRNAs are < 10 kb from hsa-mir-431
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-431 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-431-5p

Accession MIMAT0001625
Description Homo sapiens hsa-miR-431-5p mature miRNA
Evidence experimental
cloned [1-2]
Database links
Predicted targets

Mature hsa-miR-431-3p

Accession MIMAT0004757
Description Homo sapiens hsa-miR-431-3p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15891114
    Clustering and conservation patterns of human microRNAs
    "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
    "Nucleic Acids Res (2005) 33:2697-2706