Accession
MI0001723
Symbol
HGNC:
MIR433
Description
Homo sapiens
hsa-mir-433 precursor miRNA mir-433
Gene
family?
family?
RF00748;
mir-433
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR433 is a microRNA implicated in various biological processes and diseases, with its expression levels influencing cellular and molecular pathways [PMC8235499]. Studies have shown that MIR433 down-regulation may act as a tumor suppressor, as seen in its involvement in the regulation of HDAC6 expression in multiple system atrophy [PMC8235499], [PMC9025474]. Expression levels of MIR433 have been categorized into low, intermediate, and high for statistical analyses [PMC3593171]. In cancer research, the interaction between CREB1 and the MIR433 promoter has been studied to understand its role in cancer cell proliferation [PMC6326693]. Additionally, MIR433 is part of a cluster of microRNAs at the 14q32 region that may be silenced by DNA hypermethylation in bladder tumor tissues [PMC4348104], and it has been found to be downregulated in various diseases including neurodegenerative disorders like Parkinson's disease [PMC4794499]. Furthermore, it has been suggested that MIR433 targets pathways such as RAP1a and MAPK signaling to inhibit cancer cell proliferation and plays a significant role in esophageal cancer and glioma [PMC9753082]. In traumatic brain injury patients with heterotopic ossification, decreased MIR433 expression leads to increased pro-inflammatory OPN/SPP1 protein accumulation which negatively affects bone healing [PMC9753082].
Literature search
75 open access papers mention hsa-mir-433
(576 sentences)
(576 sentences)
Sequence
5947
reads,
81
reads per million, 107 experiments
ccggggagaagUACGGUGAGCCUGUCAUUAUUCagagaggcuagauccucuguguugagaaggAUCAUGAUGGGCUCCUCGGUGUucuccagg
((..((((((...(((.(((((((((((.(((((.(((((......))))).))........))).))))))))))).)))...)))))).))
((..((((((...(((.(((((((((((.(((((.(((((......))))).))........))).))))))))))).)))...)))))).))
Structure
gg gUA U U -------- g cu cc ggagaa CGG GAGCCUGUCAU AUU Ca agagg a || |||||| ||| ||||||||||| ||| || ||||| gg ccucuU GCU CUCGGGUAGUA UAg gu ucucc g -a GUG C C gaagaguu g ua
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr14: 100881886-100881978 [+]
Clustered miRNAs
6 other miRNAs are < 10 kb from hsa-mir-433
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-433 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-433-3p
| Accession | MIMAT0001627 |
| Description | Homo sapiens hsa-miR-433-3p mature miRNA |
| Sequence | 64 - AUCAUGAUGGGCUCCUCGGUGU - 85 |
| Evidence |
experimental
cloned [1-2], Illumina [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-433-5p
| Accession | MIMAT0026554 |
| Description | Homo sapiens hsa-miR-433-5p mature miRNA |
| Sequence | 12 - UACGGUGAGCCUGUCAUUAUUC - 33 |
| Evidence |
experimental
Illumina [3] |
| Database links |
|
| Predicted targets |
|
References
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