Stem-loop hsa-mir-483

Accession

MI0002467

Symbol

HGNC: MIR483

Description

Homo sapiens hsa-mir-483 precursor miRNA mir-483

Gene
family

RF03778; mir-483

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

In summary, using Cas9 immunoprecipitation we identified the oncogenic MIR483 as a critical component in the regulatory complex of IGF2 imprinting [PMC5470959]. In the present study, MIR483 was discovered to be highly expressed in the tissues of patients with BPD and may be involved in bronchial mucosal necrosis and poor repair after injury [PMC9061009]. To evaluate the phenotypic effects of MIR483 downregulation, the proliferation rate of the MIR483−/− C2C12 cells was measured in both Igf2+/+ and Igf2dGGCT cells, where the ZBED6-Igf2 axis is disrupted [PMC8484269].

Literature search

109 open access papers mention hsa-mir-483
(697 sentences)

Sequence

13812 reads, 634 reads per million, 101 experiments

gagggggAAGACGGGAGGAAAGAAGGGAGugguuccaucacgccuccUCACUCCUCUCCUCCCGUCUUcuccucuc
(((((((((((((((((((.((.((.(((.(((........)))..))).)).)).))))))))))))).))))))

Structure

      -             A  A  G   -u   ucc 
gagggg gAAGACGGGAGGA AG AG GAG  ggu   a
|||||| ||||||||||||| || || |||  |||    
cucucc cUUCUGCCCUCCU UC UC CUc  ccg   u
      u             C  C  A   cu   cac 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr11: 2134134-2134209 [-]

Disease association

hsa-mir-483 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-483-5p

• Accession: MIMAT0004761
• Description: Homo sapiens hsa-miR-483-5p mature miRNA
• Sequence: 8 - AAGACGGGAGGAAAGAAGGGAG - 29
• Evidence: experimental ; cloned [2]

Mature hsa-miR-483-3p

• Accession: MIMAT0002173
• Description: Homo sapiens hsa-miR-483-3p mature miRNA
• Sequence: 48 - UCACUCCUCUCCUCCCGUCUU - 68
• Evidence: experimental ; cloned [1-2], Northern [1]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15978578
   Identification of human fetal liver miRNAs by a novel method
   "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
   "FEBS Lett (2005) 579:3849-3854