Stem-loop hsa-mir-483

Accession

MI0002467

Symbol

HGNC: MIR483

Description

Homo sapiens hsa-mir-483 precursor miRNA mir-483

Gene
family

RF03778; mir-483

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR483 is identified as an oncogenic microRNA that plays a significant role in the regulation of IGF2 imprinting, as revealed through Cas9 immunoprecipitation techniques [PMC5470959]. This microRNA has been found to be overexpressed in the tissues of patients suffering from Bronchopulmonary Dysplasia (BPD), suggesting a potential involvement in the pathogenesis of bronchial mucosal necrosis and the impaired healing process post-injury [PMC9061009]. Furthermore, research involving MIR483 knockout (MIR483−/−) C2C12 cells has been conducted to assess its impact on cellular proliferation, particularly in cells with a disrupted ZBED6-Igf2 axis, which is crucial for understanding its phenotypic consequences [PMC8484269].

Literature search

109 open access papers mention hsa-mir-483
(697 sentences)

Sequence

13737 reads, 130 reads per million, 101 experiments

gagggggAAGACGGGAGGAAAGAAGGGAGugguuccaucacgccuccUCACUCCUCUCCUCCCGUCUUcuccucuc
(((((((((((((((((((.((.((.(((.(((........)))..))).)).)).))))))))))))).))))))

Structure

      -             A  A  G   -u   ucc 
gagggg gAAGACGGGAGGA AG AG GAG  ggu   a
|||||| ||||||||||||| || || |||  |||    
cucucc cUUCUGCCCUCCU UC UC CUc  ccg   u
      u             C  C  A   cu   cac 

Annotation confidence Medium

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr11: 2134134-2134209 [-]

Disease association

hsa-mir-483 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-483-5p

• Accession: MIMAT0004761
• Description: Homo sapiens hsa-miR-483-5p mature miRNA
• Sequence: 8 - AAGACGGGAGGAAAGAAGGGAG - 29
• Evidence: experimental ; cloned [2]

Mature hsa-miR-483-3p

• Accession: MIMAT0002173
• Description: Homo sapiens hsa-miR-483-3p mature miRNA
• Sequence: 48 - UCACUCCUCUCCUCCCGUCUU - 68
• Evidence: experimental ; cloned [1-2], Northern [1]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15978578
   Identification of human fetal liver miRNAs by a novel method
   "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
   "FEBS Lett (2005) 579:3849-3854