Accession
MI0002469
Symbol
HGNC:
MIR485
Description
Homo sapiens
hsa-mir-485 precursor miRNA mir-485
Gene
family?
family?
RF04296;
mir-485
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR485 is a microRNA implicated in various biological processes and diseases, including cancer and viral infections. It has been engineered into a genetically modified adenovirus, ICOVIR15, to enhance viral propagation and antitumor activity in pancreatic cancer cells [PMC9171400]. MIR485 is known to target RIG-I mRNA for degradation, which can impair antiviral responses and facilitate the replication of viruses such as the influenza A virus [PMC6370596]. In muscle satellite cells, MIR485 expression is associated with cell survival as its downregulation is linked to the upregulation of genes promoting cell death [PMC6655560]. Contrary to previous claims, MIR485 expression does not show any change in the liver [PMC4482373]. Additionally, MIR485 may influence Wnt signaling pathways by negatively modulating non-canonical pathway components or by positively regulating the canonical pathway during macrophage infection by certain Mycobacterium tuberculosis strains [PMC5285348]. Elevated levels of MIR485 have been reported across different organs in treated groups compared to untreated groups [PMC4605239], indicating its potential role in response to treatments or infections. Furthermore, MIR485 can interact with other microRNAs and regulatory elements like ciRs7 which may influence its activity [PMC7512242].
Literature search
64 open access papers mention hsa-mir-485
(200 sentences)
(200 sentences)
Sequence
7675
reads,
114
reads per million, 81 experiments
acuuggagAGAGGCUGGCCGUGAUGAAUUCgauucaucaaagcgaGUCAUACACGGCUCUCCUCUCUuuuagu
(((.(((((((((..(((((((((((.((((...........)))))))).)))))))..))))))))).)))
(((.(((((((((..(((((((((((.((((...........)))))))).)))))))..))))))))).)))
Structure
u CU - A auuc acu ggagAGAGG GGCCGUG AUGA UUCg a ||| ||||||||| ||||||| |||| |||| u uga uuUCUCUCC UCGGCAC UACU Gagc c u UC A - gaaa
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr14: 101055419-101055491 [+]
Clustered miRNAs
16 other miRNAs are < 10 kb from hsa-mir-485
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-485 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-485-5p
| Accession | MIMAT0002175 |
| Description | Homo sapiens hsa-miR-485-5p mature miRNA |
| Sequence | 9 - AGAGGCUGGCCGUGAUGAAUUC - 30 |
| Evidence |
experimental
array-cloned [2], cloned [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-485-3p
| Accession | MIMAT0002176 |
| Description | Homo sapiens hsa-miR-485-3p mature miRNA |
| Sequence | 46 - GUCAUACACGGCUCUCCUCUCU - 67 |
| Evidence |
experimental
cloned [1,3], array-cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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