Accession
MI0003123
Symbol
HGNC:
MIR488
Description
Homo sapiens
hsa-mir-488 precursor miRNA
Gene family
MIPF0000318;
mir-488
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR488 is a microRNA that has been identified among the differentially expressed genes in various studies [PMC4052096]. Leptin treatment has been shown to decrease the levels of MIR488 in mHypoA-POMC/GFP culture [PMC6947463]. There is evidence to suggest that MIR488 may interact with ZIP and modulate MMP-13 activity [PMC3706240]. Additionally, MIR488, along with other microRNAs such as miR30a, miR9, miR1249, and miR497, has been found to inhibit epithelial-mesenchymal transition (EMT) through MAPK signaling [PMC7602903]. A recent study has reported a relationship between MIR488 and ZIP8 in osteoarthritis, where reduced degradation of chondrocytes was observed [PMC3934988]. The roles of zinc uptake transporters like ZIP8 and MIR488 may be crucial in bone health as low bone mineral density is a common symptom of type 1 and type 2 diabetes [PMC3934988'>PMC3934988]. However, the epigenetic effect of intermittent hypoxia on the amount of MIR488 has not been confirmed yet [PMC3934988]. In Helicobacter pylori-infected gastric cancer tissues, both miR-218 and MIR488 were found to be decreased but there was no significant difference between different H. pylori strains [PMC6365042]. References: - PMC4052096 - PMC6947463 - PMC3706240 - PMC7602903 - PMC3934988 - PMC6365042
Literature search
28 open access papers mention hsa-mir-488
(167 sentences)
(167 sentences)
Sequence
607
reads,
56
reads per million, 56 experiments
gagaaucaucucuCCCAGAUAAUGGCACUCUCAAacaaguuuccaaauuguUUGAAAGGCUAUUUCUUGGUCagaugacucuc
((((.((((((..((.(((.((((((.((.((((((((.........)))))))).))))))))))).))..)))))).))))
((((.((((((..((.(((.((((((.((.((((((((.........)))))))).))))))))))).))..)))))).))))
Structure
a cu C U A C guu
gaga ucaucu CC AGA AAUGGC CU UCAAacaa u
|||| |||||| || ||| |||||| || |||||||| c
cucu aguaga GG UCU UUAUCG GA AGUUuguu c
c CU U - - A aaa
Annotation confidence
High
Do you think this miRNA is real?
Comments
miR-488-3p cloned in [2] has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
Genome context
chr1: 177029363-177029445 [-]
Disease association
hsa-mir-488 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-488-5p
| Accession | MIMAT0002804 |
| Description | Homo sapiens hsa-miR-488-5p mature miRNA |
| Sequence | 14 - CCCAGAUAAUGGCACUCUCAA - 34 |
| Evidence |
experimental
array-cloned [1] |
Mature hsa-miR-488-3p
| Accession | MIMAT0004763 |
| Description | Homo sapiens hsa-miR-488-3p mature miRNA |
| Sequence | 52 - UUGAAAGGCUAUUUCUUGGUC - 72 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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