Accession
MI0003125
Symbol
HGNC:
MIR490
Description
Homo sapiens
hsa-mir-490 precursor miRNA mir-490
Gene
family?
family?
RF00792;
mir-490
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR490 is a microRNA (miRNA) that has been identified as a potential tumor suppressor in various cancers, including bladder, lung, and ovarian cancers [PMC7287171]. It is known to target and suppress the expression of genes such as FOS, HMGA2, CCND1, and CDK1 that are involved in cell proliferation and the cell cycle [PMC7287171]. MIR490 is one of the miRNAs that are methylated in certain cell lines but not in control B cells [PMC5485978]. It has been found to target fewer than 200 genes, which is a relatively small number compared to other miRNAs such as MIR24-2 and MIR142 [PMC7287171]. In extracellular vesicles (EVs) derived from human periodontal ligament stem cells (hPDLSCs), MIR490 is one of five representative miRNAs present [PMC8308278], which suggests its role in intercellular communication. The expression of MIR490 can be regulated by CCAT1 in gastric cancer and has been shown to be negatively correlated with CCAT1 expression; high levels of MIR490 can significantly restrain gastric cancer metastasis [PMC9844612]. In lung cancer specifically, lower expression levels of MIR490 have been associated with poor survival outcomes [PMC7212445]'>PMC7212445], indicating its potential as a prognostic biomarker. Additionally, aberrant expression patterns involving MALAT1 may act as competing endogenous RNA (ceRNA), inhibiting MIR490 and leading to tumor progression through increased HMGA2 expression [PMC7212445].
Literature search
34 open access papers mention hsa-mir-490
(141 sentences)
(141 sentences)
Sequence
899
reads,
22
reads per million, 19 experiments
uggaggccuugcugguuuggaaaguucauuguucgacaCCAUGGAUCUCCAGGUGGGUcaaguuuagagaugcacCAACCUGGAGGACUCCAUGCUGuugagcuguucacaagcagcggacacuucca
((((((..((((((.(((((((........((((((((.(((((((((((((((.(((((..........)).))).)))))))))..)))))).))))))))..))).))))))))))...))))))
((((((..((((((.(((((((........((((((((.(((((((((((((((.(((((..........)).))).)))))))))..)))))).))))))))..))).))))))))))...))))))
Structure
-cc g - aguucauu C -- G - aguu
uggagg uugcug uuug gaa guucgaca CAUGGA UCUCCAGGU GGU ca u
|||||| |||||| |||| ||| |||||||| |||||| ||||||||| ||| ||
accuuc ggcgac gaac cuu cgaguuGU GUACCU GGAGGUCCA Cca gu a
aca - a ------gu C CA A c agag
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr7: 136903167-136903294 [+]
Disease association
hsa-mir-490 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-490-5p
| Accession | MIMAT0004764 |
| Description | Homo sapiens hsa-miR-490-5p mature miRNA |
| Sequence | 39 - CCAUGGAUCUCCAGGUGGGU - 58 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
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Mature hsa-miR-490-3p
| Accession | MIMAT0002806 |
| Description | Homo sapiens hsa-miR-490-3p mature miRNA |
| Sequence | 76 - CAACCUGGAGGACUCCAUGCUG - 97 |
| Evidence |
experimental
array-cloned [1] |
| Database links |
|
| Predicted targets |
|
References
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