miRBase entry: hsa-mir-490

Stem-loop hsa-mir-490

Homo sapiens hsa-mir-490 precursor miRNA
Gene family
MIPF0000229; mir-490

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR490 is a methylated miRNA that has been found in both cell lines and control B cells, as shown by methylation specific PCR (MSP) [PMC5485978]. It is also present in extracellular vesicles (EVs) derived from human periodontal ligament stem cells (hPDLSCs) [PMC7287171]. MIR490, along with MIR335 and MIR296, targets less than 200 genes each [PMC7287171]. In bladder cancer cells, MIR490 acts as a suppressor of cell proliferation by blocking the transcription of FOS [PMC7287171]. It has also been found to inhibit the expression of HMGA2 in osteosarcoma and affect the development potential of the cancer [PMC7287171]. In lung cancer cells A549 and ovarian cancer, MIR490 blocks the transcription of CCND1 and CDK1 respectively, both important genes involved in cell cycle progression [PMC7287171]. The expression of MIR490 can be regulated by CCAT1 in gastric cancer, and its high expression can decrease the expression of CCAT1 and restrain metastasis [PMC9844612]. In multiple myeloma patients, high expression levels of miR153, MIR490, miR455, miR642, miR500, and miR296 are associated with favorable prognosis [PMC6183594]. In lung adenocarcinoma (LUAD), down-regulation of MIR490 is observed while up-regulation of MALAT1 and HMGA2 is observed. The ceRNA network involving MALAT1 as a competing endogenous RNA for MIR490 may contribute to tumor progression in LUAD [PMC7212445]. Overall survival outcomes are poorer in lung cancer patients with lower expression levels of MIR490. Gain- and loss-of-function studies have shown that overexpression of MIR490 reduces proliferation, promotes G1 arrest and apoptosis, and suppresses migration and invasion [PMC7212445].

Literature search
34 open access papers mention hsa-mir-490
(141 sentences)


899 reads, 22 reads per million, 19 experiments

      -cc      g    -   aguucauu        C      --         G   -  aguu 
uggagg   uugcug uuug gaa        guucgaca CAUGGA  UCUCCAGGU GGU ca    u
||||||   |||||| |||| |||        |||||||| ||||||  ||||||||| ||| ||     
accuuc   ggcgac gaac cuu        cgaguuGU GUACCU  GGAGGUCCA Cca gu    a
      aca      -    a   ------gu        C      CA         A   c  agag 

Annotation confidence High
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Genome context
chr7: 136903167-136903294 [+]

Disease association
hsa-mir-490 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-490-5p

Accession MIMAT0004764
Description Homo sapiens hsa-miR-490-5p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-490-3p

Accession MIMAT0002806
Description Homo sapiens hsa-miR-490-3p mature miRNA
Evidence experimental
array-cloned [1]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 18230126
    New miRNAs cloned from neuroblastoma
    "Afanasyeva EA, Hotz-Wagenblatt A, Glatting KH, Westermann F"
    "BMC Genomics (2008) 9:52

  3. PubMed ID: 15965474
    Identification of hundreds of conserved and nonconserved human microRNAs
    "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
    "Nat Genet (2005) 37:766-770