Accession
MI0003127
Symbol
HGNC:
MIR511
Description
Homo sapiens
hsa-mir-511 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR511 is a microRNA implicated in various biological processes and diseases, including hepatocellular carcinoma (HCC) [PMC8369952]. It is classified under a group of microRNAs that are expressed in the alimentary system and are responsive to stimuli [PMC8369952]. MIR511, along with Mir455, has been observed to be downregulated in a rat model of diethylnitrosamine (DEN) chemically induced HCC, suggesting its potential role in the pathogenesis of this cancer [PMC8369952]. The interactions between MIR511 and the pseudogene Adh6-ps1 are of particular interest as they may contribute to the understanding of HCC; Adh6-ps1 has been found to be moderately expressed in HCC, and its association with MIR511 could indicate a regulatory role in tumorigenesis [PMC8369952]. Despite challenges in predicting targets for new microRNAs such as MIR511 due to limited sequence data [PMC2394755], studies have shown that MIR511 can enhance Bax expression, thereby inhibiting the growth of radiation-resistant A549 cells and suggesting its involvement in apoptosis mechanisms [PMC6525830].
Literature search
31 open access papers mention hsa-mir-511
(261 sentences)
(261 sentences)
Sequence
2100
reads,
68
reads per million, 62 experiments
caauagacacccaucGUGUCUUUUGCUCUGCAGUCAguaaauauuuuuuugugAAUGUGUAGCAAAAGACAGAauggugguccauug
((((.(((..((((..(((((((((((.((((.(((.((((......))))))).)))).)))))))))))..))))..))).))))
((((.(((..((((..(((((((((((.((((.(((.((((......))))))).)))).)))))))))))..))))..))).))))
Structure
a ac cG C G g ua
caau gac ccau UGUCUUUUGCU UGCA UCA uaaa u
|||| ||| |||| ||||||||||| |||| ||| ||||
guua cug ggua ACAGAAAACGA GUGU Agu guuu u
c gu AG U A - uu
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr10: 17845107-17845193 [+]
Disease association
hsa-mir-511 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-511-5p
| Accession | MIMAT0002808 |
| Description | Homo sapiens hsa-miR-511-5p mature miRNA |
| Sequence | 16 - GUGUCUUUUGCUCUGCAGUCA - 36 |
| Evidence |
experimental
array-cloned [1], Illumina [2] |
Mature hsa-miR-511-3p
| Accession | MIMAT0026606 |
| Description | Homo sapiens hsa-miR-511-3p mature miRNA |
| Sequence | 54 - AAUGUGUAGCAAAAGACAGA - 73 |
| Evidence |
experimental
Illumina [2] |
| Database links |
|
| Predicted targets |
|
References
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