Stem-loop hsa-mir-146b

Accession

MI0003129

Symbol

HGNC: MIR146B

Description

Homo sapiens hsa-mir-146b precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

Hsa-mir-146b is a microRNA (miRNA) that is notably overexpressed in peripheral blood (PB) natural killer (NK) cells [PMC3640206]. This miRNA targets TRAF6, which is involved in the regulation of the NF-kB signaling pathway, a key player in the control of immune responses and cell survival [PMC3640206]. The down-regulation of TRAF6 by hsa-mir-146b leads to a decrease in NF-kB activity, which can result in suppressed cell proliferation and increased sensitivity to chemotherapy [PMC3640206]. The expression levels of hsa-mir-146b, along with other miRNAs such as hsa-miR-375, hsa-miR-31, hsa-miR-7-2, and hsa-miR-204 were quantitatively analyzed and reported with log2 fold change and adjusted p-values to assess their relative abundance and statistical significance [PMC4918724].

Literature search

387 open access papers mention hsa-mir-146b
(2112 sentences)

Sequence

434033 reads, 1123 reads per million, 129 experiments

ccuggcacUGAGAACUGAAUUCCAUAGGCUGugagcucuagcaauGCCCUGUGGACUCAGUUCUGGUgcccgg
((.((((((.((((((((..(((((((((..((........))..).)))))))).)))))))))))))).))

Structure

  u      G        AU        - UG  agc 
cc ggcacU AGAACUGA  UCCAUAGG C  ug   u
|| |||||| ||||||||  |||||||| |  ||    
gg ccgUGG UCUUGACU  AGGUGUCC G  ac   c
  c      -        -C        C ua  gau 

Annotation confidence High

Genome context

chr10: 102436512-102436584 [+]

Disease association

hsa-mir-146b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-146b-5p

• Accession: MIMAT0002809
• Description: Homo sapiens hsa-miR-146b-5p mature miRNA
• Sequence: 9 - UGAGAACUGAAUUCCAUAGGCUG - 31
• Evidence: experimental ; array-cloned [1], cloned [2]

Mature hsa-miR-146b-3p

• Accession: MIMAT0004766
• Description: Homo sapiens hsa-miR-146b-3p mature miRNA
• Sequence: 46 - GCCCUGUGGACUCAGUUCUGGU - 67
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770