Accession
MI0003135
Symbol
HGNC:
MIR495
Description
Homo sapiens
hsa-mir-495 precursor miRNA mir-329
Gene
family?
family?
RF04295;
mir-329
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR495 is a microRNA that has been identified as possibly involved in UM tumorigenesis and/or metastasis [PMC2902045]. In a study exploring its role in the regulation of P-gp in MDR lung cancer cells, MIR495 was found to have a greatly elevated efficacy when combined with DOX in CCM/SLI/R-D, resulting in negative volume growth [PMC6841775]. In the RTT-mouse model, MIR495 was found to be significantly overexpressed and described to repress Bdnf [PMC8595945]. The binding ability of SLI to MIR495 was studied using a gel retardation assay, with naked MIR495 serving as a control [PMC6841775]. Additionally, the coating of CCM onto SLI/R-D followed a similar protocol as the binding of MIR495 [PMC6841775]. The EMT- and cancer stemness-promoting activities of intracellular GRP78 may be downregulated by certain endogenous protein factors such as DAL-1 [PMC7226806]. Overall, while limited studies are available on the role of miRNAs, including MIR495, their potential involvement in UM tumorigenesis and metastasis is being investigated [PMC2902045].
Literature search
50 open access papers mention hsa-mir-495
(177 sentences)
(177 sentences)
Sequence
10129
reads,
162
reads per million, 103 experiments
ugguaccugaaaaGAAGUUGCCCAUGUUAUUUUCGcuuuauaugugacgAAACAAACAUGGUGCACUUCUUuuucgguauca
(((((((.((((((((((.(((((((((..((((((.........).)))))..))))))).)))))))))))).)))))))
(((((((.((((((((((.(((((((((..((((((.........).)))))..))))))).)))))))))))).)))))))
Structure
u U - AU - uuu
ugguacc gaaaaGAAGU GC CCAUGUU UUUCG c a
||||||| |||||||||| || ||||||| ||||| | u
acuaugg uuuUUCUUCA CG GGUACAA AAAgc g a
c - U AC a ugu
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr14: 101033755-101033836 [+]
Clustered miRNAs
17 other miRNAs are < 10 kb from hsa-mir-495
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-495 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-495-3p
| Accession | MIMAT0002817 |
| Description | Homo sapiens hsa-miR-495-3p mature miRNA |
| Sequence | 50 - AAACAAACAUGGUGCACUUCUU - 71 |
| Evidence |
experimental
array-cloned [1], cloned [2], SOLiD [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-495-5p
| Accession | MIMAT0022924 |
| Description | Homo sapiens hsa-miR-495-5p mature miRNA |
| Sequence | 14 - GAAGUUGCCCAUGUUAUUUUCG - 35 |
| Evidence |
experimental
SOLiD [3] |
| Database links |
|
| Predicted targets |
|
References
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