Stem-loop hsa-mir-181d

Accession

MI0003139

Symbol

HGNC: MIR181D

Description

Homo sapiens hsa-mir-181d precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR181D is a microRNA implicated in various biological processes and diseases [PMC9396029]. It is located upstream of its precursor transcription start sites and has been associated with systemic lupus erythematosus susceptibility in a Chinese population [PMC9396029]. The microRNA has been shown to play a role in tumor suppression by downregulating MALT1, which inhibits tumor cell growth [PMC6125328]. However, there is no compensatory up-regulation of MIR181D observed in miR-181a/b-1 knockout thymocytes, indicating its unique regulatory functions [PMC4682956]. MIR181D also influences T helper cells by modulating the activity of the enzyme SOAT2, which is involved in cholesterol metabolism [PMC7460638]. Additionally, it can act as a transcriptional regulator by binding to DNA promoters [PMC9967498]. In the context of chronic obstructive pulmonary disease (COPD), MIR181D expression is downregulated in lung tissue, suggesting its involvement in the disease's gene regulation mechanisms [PMC6089098]. Moreover, it interacts with various biological molecules such as pseudogenes and other miRNAs as revealed by next-generation sequencing and bioinformatic analyses of COPD bronchial epithelial cells [PMC9730017].

Literature search

240 open access papers mention hsa-mir-181d
(867 sentences)

Sequence

46085 reads, 306 reads per million, 117 experiments

guccccuccccuaggccacagccgaggucacaaucAACAUUCAUUGUUGUCGGUGGGUugugaggacugaggccagacCCACCGGGGGAUGAAUGUCACuguggcugggccagacacggcuuaaggggaauggggac
(((((((((((((((((...(((..(((((((....(((((((((....((((((((((.((.(........)))))))))))))..)))))))))...))))))).))).......))))).))))))..))))))

Structure

      --      -     ----aca   ga       aucA         GUUG          g  a gac 
gucccc  uccccu aggcc       gcc  ggucaca    ACAUUCAUU    UCGGUGGGUu ug g   u
||||||  |||||| |||||       |||  |||||||    |||||||||    |||||||||| || |    
cagggg  agggga uucgg       cgg  ucggugu    UGUAAGUAG    GGCCACCcag ac c   g
      ua      a     cacagac   -g       -CAC         --GG          -  - gga 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr19: 13874875-13875011 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-181d

Disease association

hsa-mir-181d is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-181d-5p

• Accession: MIMAT0002821
• Description: Homo sapiens hsa-miR-181d-5p mature miRNA
• Sequence: 36 - AACAUUCAUUGUUGUCGGUGGGU - 58
• Evidence: experimental ; array-cloned [1], cloned [2], Illumina [3]

Mature hsa-miR-181d-3p

• Accession: MIMAT0026608
• Description: Homo sapiens hsa-miR-181d-3p mature miRNA
• Sequence: 79 - CCACCGGGGGAUGAAUGUCAC - 99
• Evidence: experimental ; Illumina [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770


3. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45