miRBase entry: hsa-mir-512-1

Stem-loop hsa-mir-512-1

HGNC: MIR512-1
Homo sapiens hsa-mir-512-1 precursor miRNA
Gene family
MIPF0000130; mir-506

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR512-1 is a miRNA gene that belongs to the C19MC miRNA gene cluster. It is a placental-specific miRNA gene that has been found to have complex methylation patterns. The promoter of the pri-miRNA for MIR512-1 is maternally methylated in placenta but fully methylated in somatic tissues [PMC3975056]. The methylation profiling of the MIR512-1 cluster has revealed that the differentially methylated region (DMR) of MIR512-1 is unmethylated in hydatidiform moles compared to partially methylated placenta [PMC3975056]. The DMR of MIR512-1 is approximately 5 kb in size and includes the promoter CpG island [PMC3975056]. Interestingly, most placental-specific DMRs, including MIR512-1, do not inherit methylation from gametes and are devoid of methylation in human embryonic stem cells [PMC3975056'>PMC3975056]. These complex methylation states at the MIR512-1 locus dictate complex allelic expression, with restricted paternal expression of the MIR512-1 pri-miRNA and reciprocal imprinting of ZNF331 [PMC3975056]. Additionally, it has been found that there may be more unknown imprinted DMRs solely present in placental tissues, as highlighted by the presence of DMRs for both MIR512-1 and GPR1-AS [PMC3975056]. The cumulative expression levels of all 46 C19MC miRNA genes, including MIR512-1, have been analyzed in breast invasive carcinoma using miRNASeq dataset [PMC6193703].

Literature search
42 open access papers mention hsa-mir-512-1
(260 sentences)


258 reads, 18 reads per million, 20 experiments

u       ug   CA      CU   G         uggug 
 cucaguc  ugg  CUCAGC  UGA GGCACUUUC     c
 |||||||  |||  ||||||  ||| |||||||||      
 gagucag  acC  GAGUCG  ACU UCGUGAAag     c
g       ua   UG      AU   G         uaaga 

Annotation confidence High
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Genome context
chr19: 53666679-53666762 [+]
Clustered miRNAs
4 other miRNAs are < 10 kb from hsa-mir-512-1
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-512-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-512-5p

Accession MIMAT0002822
Description Homo sapiens hsa-miR-512-5p mature miRNA
Evidence experimental
array-cloned [1]

Mature hsa-miR-512-3p

Accession MIMAT0002823
Description Homo sapiens hsa-miR-512-3p mature miRNA
Evidence experimental
array-cloned [1], cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15965474
    Identification of hundreds of conserved and nonconserved human microRNAs
    "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
    "Nat Genet (2005) 37:766-770