Accession
MI0003165
Symbol
HGNC:
MIR517B
Description
Homo sapiens
hsa-mir-517b precursor miRNA
Gene family
MIPF0000020;
mir-515
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Hsa-mir-517b is a microRNA that has been associated with lower cancer stages and improved patient survival [PMC7648123]. It is one of six miRNAs, including hsa-mir-517b, that have been found to be associated with stages I-III of cancer [PMC7499949]. Hsa-mir-517b is differentially expressed during NaB-induced differentiation and represents an endodermal miRNA [PMC2581805]. The presence of certain genetic mutations, such as rs1063053 and rs1063054, can affect the binding sites of hsa-mir-517b and other miRNAs [PMC5810033]. Hsa-mir-517b has been analyzed using pre-designed TaqMan® MicroRNA assays [PMC3937405]. It is important in diminishing the pluripotency state and the chondrogenic process [PMC6770352]. Hsa-mir-517b is part of the Hsa-miR-517 family, which includes three isoforms transcribed from the C19MC cluster [PMC8666996]. In summary, hsa-mir-517b is a microRNA that has been associated with lower cancer stages and improved patient survival. It is differentially expressed during NaB-induced differentiation and represents an endodermal miRNA. Certain genetic mutations can affect its binding sites. Hsa-mir-517b has been analyzed using pre-designed TaqMan® MicroRNA assays. It plays a crucial role in diminishing pluripotency state and chondrogenic process. It belongs to the Hsa-miR-517 family transcribed from the C19MC cluster.
Literature search
20 open access papers mention hsa-mir-517b
(63 sentences)
(63 sentences)
Sequence
222
reads,
19
reads per million, 26 experiments
gugacCCUCUAGAUGGAAGCACUGUCUguugucuaagaaaagAUCGUGCAUCCCUUUAGAGUGUuac
(((((.(((((((.(((.((((.((((.............)))).)))).))).))))))).)))))
(((((.(((((((.(((.((((.((((.............)))).)))).))).))))))).)))))
Structure
C U A U guugu
gugac CUCUAGA GGA GCAC GUCU c
||||| ||||||| ||| |||| |||| u
cauUG GAGAUUU CCU CGUG UAga a
U C A C aaaga
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr19: 53721076-53721142 [+]
Clustered miRNAs
9 other miRNAs are < 10 kb from hsa-mir-517b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-517b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-517-5p
| Accession | MIMAT0002851 |
| Description | Homo sapiens hsa-miR-517-5p mature miRNA |
| Sequence | 6 - CCUCUAGAUGGAAGCACUGUCU - 27 |
| Evidence |
experimental
array-cloned [1] |
Mature hsa-miR-517b-3p
| Accession | MIMAT0002857 |
| Description | Homo sapiens hsa-miR-517b-3p mature miRNA |
| Sequence | 43 - AUCGUGCAUCCCUUUAGAGUGU - 64 |
| Evidence |
experimental
array-cloned [1] |
| Database links |
|
| Predicted targets |
|
References
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