Accession
MI0003169
Symbol
HGNC:
MIR518E
Description
Homo sapiens
hsa-mir-518e precursor miRNA mir-515
Gene
family?
family?
RF00639;
mir-515
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
hsa-mir-518e is a microRNA that has been identified as upregulated in pancreatic ductal adenocarcinoma (PDAC) tissues compared to adjacent normal controls, indicating a potential role in tumorigenesis [PMC5649611]. This microRNA was also found to be significantly dysregulated in a limited number of comparisons, suggesting a more specific rather than widespread change in expression across various conditions [PMC4268797]. In the context of neural stem cell (NSC) differentiation from induced pluripotent stem cells (iPSCs), hsa-mir-518e expression is significantly decreased, which implies that it may act as a negative regulator of neural differentiation [PMC6696086]. This role is further supported by the observation that hsa-mir-518e, along with other miRNAs, was identified as potentially characteristic for the transition from iPSCs to NSCs [PMC6696086]. Additionally, hsa-mir-518e has been found to be upregulated in hepatocellular carcinoma (HCC), suggesting its involvement in multiple cancer types and highlighting its potential as a biomarker or therapeutic target [PMC5937522].
Literature search
9 open access papers mention hsa-mir-518e
(11 sentences)
(11 sentences)
Sequence
101
reads,
16
reads per million, 21 experiments
ucucaggcugugaccCUCUAGAGGGAAGCGCUUUCUGuuggcuaaaagaaaagAAAGCGCUUCCCUUCAGAGUGuuaacgcuuugaga
((((((((..((((.((((.((((((((((((((((...............)))))))))))))))).)))).))))..)).))))))
((((((((..((((.((((.((((((((((((((((...............)))))))))))))))).)))).))))..)).))))))
Structure
- ug c A Guuggc
ucucag gc ugac CUCU GAGGGAAGCGCUUUCU u
|||||| || |||| |||| |||||||||||||||| a
agaguu cg auuG GAGA UUCCCUUCGCGAAAga a
u ca U C aaagaa
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr19: 53729838-53729925 [+]
Clustered miRNAs
9 other miRNAs are < 10 kb from hsa-mir-518e
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-518e is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-518e-5p
| Accession | MIMAT0005450 |
| Description | Homo sapiens hsa-miR-518e-5p mature miRNA |
| Sequence | 16 - CUCUAGAGGGAAGCGCUUUCUG - 37 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-518e-3p
| Accession | MIMAT0002861 |
| Description | Homo sapiens hsa-miR-518e-3p mature miRNA |
| Sequence | 54 - AAAGCGCUUCCCUUCAGAGUG - 74 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
References
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