Stem-loop hsa-mir-499a

Accession

MI0003183

Symbol

HGNC: MIR499A

Description

Homo sapiens hsa-mir-499a precursor miRNA mir-499

Gene
family

RF00745; mir-499

Literature search

136 open access papers mention hsa-mir-499a
(778 sentences)

Sequence

67945 reads, 526 reads per million, 101 experiments

gcccuguccccugugccuugggcgggcggcugUUAAGACUUGCAGUGAUGUUUaacuccucuccacgugAACAUCACAGCAAGUCUGUGCUgcuucccgucccuacgcugccugggcagggu
(((((((((.....((...(((((((.(((.((..((((((((.((((((((((.............)))))))))).))))))))..)).))).)))).)))...)).....)))))))))

Structure

         ccugu  cuu   -    c   u  UA        A          acucc 
gcccugucc     gc   ggg cggg ggc gU  AGACUUGC GUGAUGUUUa     u
|||||||||     ||   ||| |||| ||| ||  |||||||| ||||||||||     c
ugggacggg     cg   ccc gccc ucg CG  UCUGAACG CACUACAAgu     u
         uccgu  cau   u    u   U  UG        A          gcacc 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr20: 34990376-34990497 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-499a

Disease association

hsa-mir-499a is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-499a-5p

• Accession: MIMAT0002870
• Description: Homo sapiens hsa-miR-499a-5p mature miRNA
• Sequence: 33 - UUAAGACUUGCAGUGAUGUUU - 53
• Evidence: experimental ; array-cloned [1], cloned [2]

Mature hsa-miR-499a-3p

• Accession: MIMAT0004772
• Description: Homo sapiens hsa-miR-499a-3p mature miRNA
• Sequence: 70 - AACAUCACAGCAAGUCUGUGCU - 91
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770