Stem-loop hsa-mir-509-1

Accession

MI0003196

Symbol

HGNC: MIR509-1

Description

Homo sapiens hsa-mir-509-1 precursor miRNA mir-509

Gene
family

RF04216; mir-509

Literature search

31 open access papers mention hsa-mir-509-1
(221 sentences)

Sequence

51808 reads, 1214 reads per million, 43 experiments

caugcugugugugguacccUACUGCAGACAGUGGCAAUCAuguauaauuaaaaaUGAUUGGUACGUCUGUGGGUAGaguacugcaugacacaug
((((.((((((((((((.(((((((((((.(((.(((((((............))))))).))))))))).))))).))))))))).)))))))

Structure

    c   -         c     -      A   G       guaua 
caug ugu gugugguac cUACU GCAGAC GUG CAAUCAu     a
|||| ||| ||||||||| ||||| |||||| ||| |||||||      
guac aca uacgucaug GAUGG UGUCUG CAU GUUAGUa     u
    -   g         a     G      -   G       aaaau 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3]. The cloned miR-509-5p sequence from [3] includes a 1 nt extension at the 3' end (A), which is incompatible with the genome sequence.

Genome context

chrX: 147260532-147260625 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-509-1

Disease association

hsa-mir-509-1 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-509-5p

• Accession: MIMAT0004779
• Description: Homo sapiens hsa-miR-509-5p mature miRNA
• Sequence: 20 - UACUGCAGACAGUGGCAAUCA - 40
• Evidence: experimental ; cloned [3]

Mature hsa-miR-509-3p

• Accession: MIMAT0002881
• Description: Homo sapiens hsa-miR-509-3p mature miRNA
• Sequence: 55 - UGAUUGGUACGUCUGUGGGUAG - 76
• Evidence: experimental ; array-cloned [1], cloned [2-3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770


3. PubMed ID: 17573847
   Analysis of gene expression in normal and neoplastic human testis: new roles of RNA
   "Novotny GW, Nielsen JE, Sonne SB, Skakkebaek NE, Rajpert-De Meyts E, Leffers H"
   "Int J Androl (2007) 30:316-326