miRBase entry: hsa-mir-455

Stem-loop hsa-mir-455

Homo sapiens hsa-mir-455 precursor miRNA
Gene family
MIPF0000129; mir-455

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR455 is a microRNA that is implicated in various diseases and conditions. It is specifically linked with hepatocellular carcinoma (HCC), gastric cancer (GC), and colorectal cancer (CRC) [PMC8369952]. In addition, MIR455 is associated with endometrial cancers [PMC8369952]. It has been found that certain microRNAs, including MIR455, regulate brown adipocyte differentiation [PMC7123371]. In multiple myeloma patients, high expression of MIR455 is considered a favorable prognostic factor [PMC6183594]. Furthermore, irregular expression of MIR455 has been observed in patients with preeclampsia, suggesting its potential role in the pathogenesis of the condition [PMC4540200]. Interestingly, MIR455 has also been detected in the exosomal population after exercise in type 2 diabetic mice, indicating that its content varies depending on the cells of origin at the time of secretion [PMC4568920].

MIR455 and Mir511 are largely expressed in the alimentary system and are involved in response to stimulus processes [PMC8369952]. In terms of cardiovascular health, MIR455 has been found to be cardioprotective in type 1 diabetes mellitus (T1DM) while Mir22 plays a similar role in type 2 diabetes mellitus (T2DM) [PMC7593653].

The formation of MIR455 is induced by cold temperature exposure and BMP7. This induction is necessary for the development of both brown adipose tissue (BAT) and recruitable beige adipose tissue (BeAT) [PMC7123371].

To verify predicted targets for MIR455 and to test its functionality within miRNA-induced silencing complex (miRISC), a dual luciferase-based miRNA-activity reporter assay was adopted. This assay involved renilla luciferase (RL) and firefly luciferase (FL) reporter genes [PMC4540200]. The observed elevation in mature MIR455 in BeWo cells upon FSK treatment can be attributed to increased expression of the COL27A1 gene [PMC4540200].

Literature search
75 open access papers mention hsa-mir-455
(620 sentences)


49975 reads, 927 reads per million, 127 experiments

----ucccu   -g     -----          U      A   C   gaa 
         ggc  ugagg     gUAUGUGCCU UGGACU CAU Gug   g
         |||  |||||     |||||||||| |||||| ||| |||    
         ccg  acucc     CAUAUACGGG ACCUGA Gua cac   c
cuacuguau   ga     guuCA          U      C   c   gac 

Annotation confidence Not enough data
Do you think this miRNA is real?
The mir-455 precursor was predicted computationally and a 5' mature product verified in human by Northern blot [1]. The precise sequence termini of the mature forms were derived by cloning from human and rat samples [2].

Genome context
chr9: 114209434-114209529 [+]

Disease association
hsa-mir-455 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-455-5p

Accession MIMAT0003150
Description Homo sapiens hsa-miR-455-5p mature miRNA
Evidence experimental
Northern [1], cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-455-3p

Accession MIMAT0004784
Description Homo sapiens hsa-miR-455-3p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 15652478
    Phylogenetic shadowing and computational identification of human microRNA genes
    "Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E"
    "Cell (2005) 120:21-24