Accession
MI0003599
Symbol
HGNC:
MIR589
Description
Homo sapiens
hsa-mir-589 precursor miRNA mir-589
Gene
family?
family?
RF00987;
mir-589
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR589 is a miRNA gene located in the chromosomal region 7p22, which is prone to gaps and breaks in various cancers [PMC3634031]. In a study comparing different populations, it was found that MIR589 was the only differentially methylated and expressed miRNA in individuals of European ancestry [PMC8453167]. Several other miRNAs, including MIR589, have been identified as overexpressed in breast cancer and have potential applications in diagnosis, prognosis, and therapeutic studies [PMC4508501]. In an experiment investigating the effect of TGFβ1 on MIR589 expression, it was observed that TGFβ1 treatment decreased the expression of MIR589 [PMC3479401]. The decreased expression of MIR589 was also observed in human peritoneal mesothelial cells (HPMCs) isolated from peritoneal dialysis patients and HMrSV5 cells treated with TGFβ1 [PMC3479401]. Additionally, a study on IFN-γ stimulation identified MIR589 as one of the top 10 upregulated miRNAs [PMC8010072]. Overall, these findings highlight the potential role of MIR589 in cancer development and progression.
Literature search
15 open access papers mention hsa-mir-589
(37 sentences)
(37 sentences)
Sequence
5972
reads,
91
reads per million, 108 experiments
uccagccugugcccagcagccccUGAGAACCACGUCUGCUCUGAGcuggguacugccuguUCAGAACAAAUGCCGGUUCCCAGAcgcugccagcuggcc
.(((((.((......(((((..(((.(((((.(((.((.(((((((.((......)).))))))).)).)))..))))).)))..))))))))))))..
.(((((.((......(((((..(((.(((((.(((.((.(((((((.((......)).))))))).)).)))..))))).)))..))))))))))))..
Structure
-u c ugccca cc A -A C C u gu ccagc ug gcagc cUG GAACC CGU UG UCUGAGc gg a ||||| || ||||| ||| ||||| ||| || ||||||| || ggucg ac cgucg GAC CUUGG GUA AC AGACUug cc c cc - ------ cA C CC A A u gu
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr7: 5495819-5495917 [-]
Disease association
hsa-mir-589 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-589-5p
| Accession | MIMAT0004799 |
| Description | Homo sapiens hsa-miR-589-5p mature miRNA |
| Sequence | 24 - UGAGAACCACGUCUGCUCUGAG - 45 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-589-3p
| Accession | MIMAT0003256 |
| Description | Homo sapiens hsa-miR-589-3p mature miRNA |
| Sequence | 61 - UCAGAACAAAUGCCGGUUCCCAGA - 84 |
| Evidence |
experimental
SAGE [1] |
| Database links |
|
| Predicted targets |
|
References
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