Accession
MI0003602
Symbol
HGNC:
MIR590
Description
Homo sapiens
hsa-mir-590 precursor miRNA mir-590
Gene
family?
family?
RF00928;
mir-590
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR590 is a microRNA that has been observed to be upregulated in various pathological conditions [PMC7652879]. It is regulated by an ERα binding site in its promoter region, located approximately 1050 bp upstream from its transcription start site [PMC6328622]. MIR590 has been implicated in the regulation of genes associated with synaptic maturation, as well as the modulation of TGFβR2, which is a key player in epithelial-mesenchymal transition (EMT) [PMC9685394], [PMC4626157]. Furthermore, MIR590 has been shown to target Tob1 within exosomes and exert effects that influence cellular processes [PMC9564062]. In cardiovascular research, MIR590 has been identified as an inhibitor of cardiac fibrosis post-myocardial infarction and is closely associated with myocarditis and heart failure (HF) [PMC9589260], [PMC5460483]. It also plays a role in oncogenesis by targeting PPM1F and serves as a prognostic factor for tumor recurrence [PMC8743668]. Additionally, MIR590's involvement in EMT is well-documented alongside other microRNAs like miR182 and miR183 [PMC7575175]. Its expression levels have also been found to be significantly altered in various diseases such as pancreatitis and breast cancer (BRCA), indicating its potential role as a biomarker for these conditions [PMC9599289], [PMC10137353].
Literature search
68 open access papers mention hsa-mir-590
(418 sentences)
(418 sentences)
Sequence
92304
reads,
292
reads per million, 152 experiments
uagccagucagaaauGAGCUUAUUCAUAAAAGUGCAGuauggugaagucaaucugUAAUUUUAUGUAUAAGCUAGUcucugauugaaacaugcagca
....((((((((.((.(((((((.(((((((.(((((..(((.....)))..))))).))))))).))))))).)).))))))))............
....((((((((.((.(((((((.(((((((.(((((..(((.....)))..))))).))))))).))))))).)).))))))))............
Structure
--------uagc a G U G ua u
cagucaga au AGCUUAU CAUAAAA UGCAG ugg g
|||||||| || ||||||| ||||||| ||||| ||| a
guuagucu UG UCGAAUA GUAUUUU AUguc acu a
acgacguacaaa c A U A ua g
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr7: 74191198-74191294 [+]
Disease association
hsa-mir-590 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-590-5p
| Accession | MIMAT0003258 |
| Description | Homo sapiens hsa-miR-590-5p mature miRNA |
| Sequence | 16 - GAGCUUAUUCAUAAAAGUGCAG - 37 |
| Evidence |
experimental
Microarray [1], SAGE [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-590-3p
| Accession | MIMAT0004801 |
| Description | Homo sapiens hsa-miR-590-3p mature miRNA |
| Sequence | 56 - UAAUUUUAUGUAUAAGCUAGU - 76 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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