Accession
MI0003618
Symbol
HGNC:
MIR605
Description
Homo sapiens
hsa-mir-605 precursor miRNA mir-605
Gene
family?
family?
RF01011;
mir-605
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR605 is a microRNA that has been found to regulate the p53-MDM2 interaction and is a transcriptional target of p53, participating in a positive feedback loop by degrading MDM2 [PMC3248149]. However, the allelic and genotypic frequencies of the SNVs selected in TP53, MDM2, MIR605, and LIF were not statistically different between CZS and control groups [PMC8294037]. In a study evaluating the effect of ZIKV infection on gene expression in human neuroprogenitor cells (hNPCs), it was found that ZIKV infection did not alter the expression of MIR605 [PMC8294037]. One polymorphism in the MIR605 gene (rs2043556) was significantly associated with infectious-type toxicity during ALL treatment [PMC10003057]. This variant has also been linked to the development of various cancers and may affect the functionality of the MIR605 processing gene [PMC10003057]. Additionally, it was found that variants in genes such as MIR149, MIR938, MIR200C, and MIR2053 were associated with neurological toxicity during ALL treatment [PMC10003057]. These findings suggest that variants in genes like MIR149 and MIR605 can influence toxicity during cancer treatment by playing regulatory roles in cellular environments [PMC10003057]. Overall, these studies highlight the importance of microRNAs like MIR605 in regulating gene expression and their potential role as biomarkers for treatment response or toxicity prediction.
Literature search
10 open access papers mention hsa-mir-605
(37 sentences)
(37 sentences)
Sequence
472
reads,
139
reads per million, 51 experiments
gcccuagcuugguucUAAAUCCCAUGGUGCCUUCUCCUugggaaaaacagAGAAGGCACUAUGAGAUUUAGAaucaaguuagg
..(((((((((((((((((((.((((((((((((((..((.......)))))))))))))))).)))))))))))))))))))
..(((((((((((((((((((.((((((((((((((..((.......)))))))))))))))).)))))))))))))))))))
Structure
gc C CU gg ccuagcuugguucUAAAUC CAUGGUGCCUUCUC ug a ||||||||||||||||||| |||||||||||||| || a ggauugaacuaAGAUUUAG GUAUCACGGAAGAg ac a -- A -- aa
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr10: 51299573-51299655 [+]
Disease association
hsa-mir-605 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-605-5p
| Accession | MIMAT0003273 |
| Description | Homo sapiens hsa-miR-605-5p mature miRNA |
| Sequence | 16 - UAAAUCCCAUGGUGCCUUCUCCU - 38 |
| Evidence |
experimental
SAGE [1] |
Mature hsa-miR-605-3p
| Accession | MIMAT0026621 |
| Description | Homo sapiens hsa-miR-605-3p mature miRNA |
| Sequence | 51 - AGAAGGCACUAUGAGAUUUAGA - 72 |
| Evidence |
experimental
Illumina [2] |
| Database links |
|
| Predicted targets |
|
References
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