Stem-loop hsa-mir-625

Accession

MI0003639

Symbol

HGNC: MIR625

Description

Homo sapiens hsa-mir-625 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

Hsa-mir-625 is a microRNA that has been found to be down-regulated in various conditions, including Alzheimer's disease (AD) [PMC3205057]. It is one of the microRNAs predicted to target multiple genes associated with AD [PMC9312389]. Hsa-mir-625 has also been identified as one of the miRNAs that can be used to distinguish different types of lymphomas [PMC4335255]. Additionally, it has been found to be differentially expressed in various cancers, including breast cancer [PMC6412941] and pancreatic cancer [PMC7942015]. The upregulation of hsa-mir-625 has been investigated for its effect on apoptosis and proliferation in a specific cell line [PMC9375600]. In human oocytes, hsa-mir-625 was found to be up-regulated in mature oocytes compared to immature ones [PMC4919285]. The variant deletion allele of hsa-mir-625 has been associated with changes in its minimum free energy (MFE) and potential target sites for other miRNAs have been identified within its sequence [PMC3444488] [PMC4008537]. Hsa-mir-625 is also mentioned as one of the miRNA precursors with previously unreported antisense transcripts [PMC3722126]. Finally, it has been identified as one of the RNA molecules transferred from pancreatic cancer cells to osteoblasts via small extracellular vesicles (sEVs) for intercellular communication [PMC8056276].

Literature search

40 open access papers mention hsa-mir-625
(457 sentences)

Sequence

26318 reads, 196 reads per million, 124 experiments

aggguagagggaugAGGGGGAAAGUUCUAUAGUCCuguaauuagaucucagGACUAUAGAACUUUCCCCCUCAucccucugcccu
(((((((((((((((((((((((((((((((((((((...........)))))))))))))))))))))))))))))))))))))

Structure

                                     uaau 
aggguagagggaugAGGGGGAAAGUUCUAUAGUCCug    u
|||||||||||||||||||||||||||||||||||||    a
ucccgucucccuACUCCCCCUUUCAAGAUAUCAGgac    g
                                     ucua 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr14: 65471102-65471186 [+]

Disease association

hsa-mir-625 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-625-5p

• Accession: MIMAT0003294
• Description: Homo sapiens hsa-miR-625-5p mature miRNA
• Sequence: 15 - AGGGGGAAAGUUCUAUAGUCC - 35
• Evidence: experimental ; Microarray [1], RT-PCR [1], SAGE [1], cloned [2]

Mature hsa-miR-625-3p

• Accession: MIMAT0004808
• Description: Homo sapiens hsa-miR-625-3p mature miRNA
• Sequence: 52 - GACUAUAGAACUUUCCCCCUCA - 73
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16505370
   The colorectal microRNAome
   "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
   "Proc Natl Acad Sci U S A (2006) 103:3687-3692