Stem-loop hsa-mir-625

Accession

MI0003639

Symbol

HGNC: MIR625

Description

Homo sapiens hsa-mir-625 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

Hsa-mir-625 is a microRNA that has been identified as down-regulated in certain studies and is implicated in various biological processes and diseases [PMC3205057]. It is one of the microRNAs predicted to target genes associated with Alzheimer's disease [PMC9312389] and has been included in a minimal set of miRNAs to distinguish between different types of peripheral T-cell lymphomas [PMC4335255]. Hsa-mir-625 is also among the top differentially expressed miRNAs (DEmiRs) identified in certain screenings, suggesting its potential as a biomarker [PMC5759858]. It has been found to be distinctively expressed in smooth muscle cells, indicating its role in cellular differentiation [PMC8082160]. Furthermore, hsa-mir-625 has associations with breast cancer (BC) known disease genes and miRNAs, highlighting its relevance to cancer progression and potential as a prognostic marker [PMC6412941], [PMC7942015]. Studies have also investigated the effect of hsa-mir-625 upregulation on apoptosis and proliferation through the ILK signaling pathway, suggesting its functional significance in cellular processes [PMC9375600]. Additionally, hsa-mir-625 expression levels have been observed to vary between different stages of oocyte maturation [PMC4919285], indicating its role in developmental biology. Its expression was found upregulated in bile duct cancer as well, further underscoring its importance in oncology research [PMC5073992].

Literature search

40 open access papers mention hsa-mir-625
(457 sentences)

Sequence

26318 reads, 196 reads per million, 124 experiments

aggguagagggaugAGGGGGAAAGUUCUAUAGUCCuguaauuagaucucagGACUAUAGAACUUUCCCCCUCAucccucugcccu
(((((((((((((((((((((((((((((((((((((...........)))))))))))))))))))))))))))))))))))))

Structure

                                     uaau 
aggguagagggaugAGGGGGAAAGUUCUAUAGUCCug    u
|||||||||||||||||||||||||||||||||||||    a
ucccgucucccuACUCCCCCUUUCAAGAUAUCAGgac    g
                                     ucua 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr14: 65471102-65471186 [+]

Disease association

hsa-mir-625 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-625-5p

• Accession: MIMAT0003294
• Description: Homo sapiens hsa-miR-625-5p mature miRNA
• Sequence: 15 - AGGGGGAAAGUUCUAUAGUCC - 35
• Evidence: experimental ; Microarray [1], RT-PCR [1], SAGE [1], cloned [2]

Mature hsa-miR-625-3p

• Accession: MIMAT0004808
• Description: Homo sapiens hsa-miR-625-3p mature miRNA
• Sequence: 52 - GACUAUAGAACUUUCCCCCUCA - 73
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16505370
   The colorectal microRNAome
   "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
   "Proc Natl Acad Sci U S A (2006) 103:3687-3692