miRBase entry: hsa-mir-33b

Stem-loop hsa-mir-33b

Homo sapiens hsa-mir-33b precursor miRNA
Gene family
MIPF0000070; mir-33

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR33B is a small long-coding RNA that is constitutively under-expressed in multiple myeloma (MM) patients [PMC5721125]. Overexpression of MIR33B has been shown to inhibit tumor growth and increase survival in a human MM xenograft mice model [PMC5721125]. Under baseline conditions, oxLDL has been found to decrease the levels of MIR33B [PMC4945056]. However, pitavastatin has been shown to prevent the suppression of MIR33B by oxLDL [PMC4945056]. Silencing MIR33B has been found to reverse cordycepin-mediated suppression of invasive and migratory phenotypes in vitro and melanoma metastasis in vivo [PMC4496401]. Ixazomib treatment has been shown to induce upregulation of MIR33B in MM cells, leading to apoptosis by blocking the proto-oncogene PIM-1 [PMC7236745]. MIR33B is located in intron 17 of the SREBF-1 gene on chromosome 17 [PMC3639327]. Rodents lack the MIR33B gene in the SREBF-1 gene [PMC3639327]. Plasma levels of miR-33a and MIR33B have been found to be upregulated in familial hypercholesterolaemic children and positively correlated with LDL-C, LDL-C/HDL-C ratio, apolipoprotein B, CRP, and glycaemia [PMC5113745]. The transfer of MIR33B from MSCs to astrocytes through exosome-downregulated connected tissue growth factor expression can reduce glial scarring and promote neurite growth [PMC6038041].
Mentioned studies:
[PMC5721125] - Study on microRNA profiling of MM cells treated with ixazomib
[PMC4945056] - Study on the effect of oxLDL on miRNA levels
[PMC4496401] - Study on the role of MIR33B in cordycepin-mediated suppression
[PMC7236745] - Study on the effect of ixazomib treatment on MIR33B expression in MM cells
[PMC3639327] - Study on the location of MIR33B in the SREBF-1 gene
[PMC5113745] - Study on plasma levels of miR-33a and MIR33B in familial hypercholesterolaemic children
[PMC6038041] - Study on the transfer of MIR33B from MSCs to astrocytes

Literature search
121 open access papers mention hsa-mir-33b
(1295 sentences)


9053 reads, 221 reads per million, 86 experiments

-----  ---    -   c   c  -          UU         g   g 
     gc   gggc ggc ccg gG UGCAUUGCUG  GCAUUGCac ugu u
     ||   |||| ||| ||| || ||||||||||  ||||||||| ||| g
     cg   cccg ccg ggC CC ACGUGACGGC  CGUGACgug gcg a
cacca  guc    g   a   -  G          UC         g   g 

Annotation confidence High
Do you think this miRNA is real?
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr17: 17813836-17813931 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-33b
Name Accession Chromosome Start End Strand Confidence

Biological pathways
hsa-mir-33b is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-33b is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-33b-5p

Accession MIMAT0003301
Description Homo sapiens hsa-miR-33b-5p mature miRNA
Evidence experimental
SAGE [1], cloned [2]
Database links
Predicted targets

Mature hsa-miR-33b-3p

Accession MIMAT0004811
Description Homo sapiens hsa-miR-33b-3p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16505370
    The colorectal microRNAome
    "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
    "Proc Natl Acad Sci U S A (2006) 103:3687-3692