Stem-loop hsa-mir-641

Accession

MI0003656

Symbol

HGNC: MIR641

Description

Homo sapiens hsa-mir-641 precursor miRNA mir-641

Gene
family

RF03629; mir-641

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR641 is a microRNA implicated in the regulation of gene expression and has been associated with various cancers, including colorectal cancer [PMC2885343]. In the context of testicular germ cell cancer (TGCC), MIR641 has been shown to play a role in the pathogenesis by downregulating PTGDS gene expression following DMRT1 repression in human fetal testis [PMC6195803]. When human fetal testis tissue was transduced with MIR641, a reduction in DMRT1 protein levels was observed, particularly in second-trimester tissue, without affecting SOX9 expression [PMC6195803]. Additionally, MIR641 transduction resulted in a significant reduction of R-spondin 1 and SOX8 expression, indicating its influence on Sertoli cell-associated genes [PMC6195803]. However, due to considerable inter-individual variation between fetuses, no significant difference in DMRT1 gene expression was observed in tissues exposed to MIR641 when compared to scrambled miRNA-exposed control tissue [PMC6195803'>PMC6195803]. Moreover, exposure to MIR641 disrupted normal seminiferous cord structure within the testes [PMC6195803]. These findings suggest that MIR641 has functional significance within the human fetal testis by targeting genes associated with male reproductive development and may contribute to TGCC pathogenesis through its regulatory effects on DMRT1 and associated pathways [PMC6195803].

Literature search

10 open access papers mention hsa-mir-641
(32 sentences)

Sequence

5404 reads, 167 reads per million, 112 experiments

ugggugaaaggaaggAAAGACAUAGGAUAGAGUCACCUCuguccucuguccucuaccuauagaggugacuguccuaugucuuuccuuccucuuaccccu
.((((((.((((((((((((((((((((..((((((((((((.....(....).....)))))))))))))))))))))))))))))))).))))))..

Structure

-u      a                    AG            ccucu u 
  ggguga aggaaggAAAGACAUAGGAU  AGUCACCUCugu     g c
  |||||| ||||||||||||||||||||  ||||||||||||     |  
  cccauu uccuuccuuucuguauccug  ucaguggagaua     c c
uc      c                    --            uccau u 

Annotation confidence Not enough data

Genome context

chr19: 40282543-40282641 [-]

Disease association

hsa-mir-641 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-641

• Accession: MIMAT0003311
• Description: Homo sapiens hsa-miR-641 mature miRNA
• Sequence: 16 - AAAGACAUAGGAUAGAGUCACCUC - 39
• Evidence: experimental ; SAGE [1]

References

1. PubMed ID: 16505370
   The colorectal microRNAome
   "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
   "Proc Natl Acad Sci U S A (2006) 103:3687-3692