MIR651 is a microRNA that is deleted in certain genetic conditions, such as DGDP289B, and is also positively correlated with the development of hepatocellular carcinoma (HCC) [PMC3929543] [PMC7019335] [PMC9495750]. The variant allele (C) of rs149259359 may disrupt binding sites for several miRNAs, including MIR651 [PMC6969370]. In a patient with a genetic disorder, a copy number gain at Xp22.31 encompassed the MIR651 gene [PMC4498854]. MIR651 is one of several miRNAs that positively correlated with serum IP10 and MCP-1 levels and were more commonly observed in individuals who developed HCC [PMC9495750]. In addition to HCC development, MIR651 has been found to have intimate interactions with other miRNAs such as MIR193A, MIR140, MIR214, MIR34A, and MIR130A [PMC6714963]. Overall, the research suggests that MIR651 plays a role in genetic conditions and HCC development.
---------aau a c A GA ucaaa cu uca ugcuuUUUAGGAUA GCUU CUUUUGu u || ||| |||||||||||||| |||| ||||||| ga agu acgGAAAAUCCUAU UGAA GAAAacg a uuuguguaauuu c a G AG uaaaa
Disease | Description | Category | PubMed ID |
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Accession | MIMAT0003321 |
Description | Homo sapiens hsa-miR-651-5p mature miRNA |
Sequence | 16 - UUUAGGAUAAGCUUGACUUUUG - 37 |
Evidence |
experimental
RT-PCR [1], SAGE [1], cloned [2], Illumina [3] |
Database links |
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Predicted targets |
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Accession | MIMAT0026624 |
Description | Homo sapiens hsa-miR-651-3p mature miRNA |
Sequence | 54 - AAAGGAAAGUGUAUCCUAAAAG - 75 |
Evidence |
experimental
Illumina [3] |
Database links |
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Predicted targets |
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