Accession
MI0003666
Symbol
HGNC:
MIR651
Description
Homo sapiens
hsa-mir-651 precursor miRNA mir-651
Gene
family?
family?
RF00972;
mir-651
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR651 is a microRNA implicated in various genetic contexts, including a 1.69 Mb copy number gain at Xp22.31, which encompasses several genes and microRNAs [PMC4498854]. It is not mentioned as part of the 4.96 Mb loss on chromosome 6 but is included in the 1.69 Mb gain on chromosome X, suggesting its potential involvement in genomic structural variations [PMC4498854]. PolymiRTS analysis indicates that the C allele of rs149259359 may create novel binding sites for MIR651, among other miRNAs, which could influence gene regulation [PMC6969370]. Furthermore, MIR651 has been shown to correlate positively with serum levels of IP10 and MCP-1, two inflammatory markers associated with hepatocellular carcinoma (HCC) development, and this correlation was more pronounced in patients who developed HCC compared to controls [PMC9495750]. Additionally, MIR651 was found to interact with the long non-coding RNA LINC01106 along with other miRNAs, suggesting its role in complex regulatory networks that could be relevant to disease mechanisms or progression [PMC6714963].
Literature search
3 open access papers mention hsa-mir-651
(3 sentences)
(3 sentences)
Sequence
1816
reads,
90
reads per million, 114 experiments
aaucuaucacugcuuUUUAGGAUAAGCUUGACUUUUGuucaaauaaaaaugcaAAAGGAAAGUGUAUCCUAAAAGgcaaugacaguuuaauguguuu
...((.(((.((((((((((((((.((((..(((((((............)))))))..)))).)))))))))))))).))).))............
...((.(((.((((((((((((((.((((..(((((((............)))))))..)))).)))))))))))))).))).))............
Structure
---------aau a c A GA ucaaa
cu uca ugcuuUUUAGGAUA GCUU CUUUUGu u
|| ||| |||||||||||||| |||| |||||||
ga agu acgGAAAAUCCUAU UGAA GAAAacg a
uuuguguaauuu c a G AG uaaaa
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chrX: 8126965-8127061 [+]
Disease association
hsa-mir-651 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-651-5p
| Accession | MIMAT0003321 |
| Description | Homo sapiens hsa-miR-651-5p mature miRNA |
| Sequence | 16 - UUUAGGAUAAGCUUGACUUUUG - 37 |
| Evidence |
experimental
RT-PCR [1], SAGE [1], cloned [2], Illumina [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-651-3p
| Accession | MIMAT0026624 |
| Description | Homo sapiens hsa-miR-651-3p mature miRNA |
| Sequence | 54 - AAAGGAAAGUGUAUCCUAAAAG - 75 |
| Evidence |
experimental
Illumina [3] |
| Database links |
|
| Predicted targets |
|
References
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