Accession
MI0003667
Symbol
HGNC:
MIR652
Description
Homo sapiens
hsa-mir-652 precursor miRNA mir-652
Gene
family?
family?
RF00872;
mir-652
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR652 is a microRNA that has been studied in various contexts. In the EOMG subgroup, MIR652 was found to be in low levels, along with other miRNAs such as miR518d, let7g, miR-192, miR24, miR15b, let7e, miR221, miR-345, miR20b, miR-140 and miR331 [PMC3956820]. In both KO and KI mice models, MIR652 was upregulated and negatively regulated spermatid differentiation [PMC10001410]. In breast cancer cases versus controls, MIR652 was found to be downregulated in serum samples [PMC9967215]. Furthermore, MIR652 was identified as a potential biomarker for breast cancer in multiple independent clinical studies [PMC9967215]. Additionally, the expression of MIR652 has been analyzed in relation to tumor relapse and overall survival in patients with triple-negative breast cancer (TNBC) [PMC7392022]. A four-miRNA signature consisting of MIR18b (miRNA-18b), MIR103 (miRNA-103), MIR107 (miRNA-107), and MIR652 was found to be predictive of tumor relapse and overall survival in TNBC patients [PMC7392022]. Overall, these studies highlight the potential role of MIR652 as a biomarker for various diseases and its involvement in spermatid differentiation.
Literature search
34 open access papers mention hsa-mir-652
(107 sentences)
(107 sentences)
Sequence
50720
reads,
420
reads per million, 123 experiments
acgaauggcuaugcacugcaCAACCCUAGGAGAGGGUGCCAUUCAcauagacuauaauugAAUGGCGCCACUAGGGUUGUGcagugcacaaccuacac
......((...((((((((((((((((((.....(((((((((((..((.....))..))))))))))).))))))))))))))))))...)).....
......((...((((((((((((((((((.....(((((((((((..((.....))..))))))))))).))))))))))))))))))...)).....
Structure
acgaau cua GAGAG ca g
gg ugcacugcaCAACCCUAG GGUGCCAUUCA ua a
|| |||||||||||||||||| ||||||||||| || c
cc acgugacGUGUUGGGAUC CCGCGGUAAgu au u
-cacau aac ----A ua a
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 3' end of the miRNA is offset with respect to previous annotations. miR-652 cloned in [2] has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
Genome context
chrX: 110055329-110055426 [+]
Disease association
hsa-mir-652 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-652-3p
| Accession | MIMAT0003322 |
| Description | Homo sapiens hsa-miR-652-3p mature miRNA |
| Sequence | 61 - AAUGGCGCCACUAGGGUUGUG - 81 |
| Evidence |
experimental
Microarray [1], SAGE [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-652-5p
| Accession | MIMAT0022709 |
| Description | Homo sapiens hsa-miR-652-5p mature miRNA |
| Sequence | 21 - CAACCCUAGGAGAGGGUGCCAUUCA - 45 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
|
References
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