Stem-loop hsa-mir-663a

Accession

MI0003672

Symbol

HGNC: MIR663A

Description

Homo sapiens hsa-mir-663a precursor miRNA mir-663

Gene
family

RF00957; mir-663

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR663A is a microRNA that has been found to suppress colorectal cancer (CC) metastasis [PMC6365692]. In contrast, TTC22V1 has been shown to promote CC metastasis [PMC6365692]. The significance of MIR663A downregulation by MALAT1 was evaluated by studying the expression changes of a set of MIR663A target genes, including P5319, PIK3CD12, P2111, CXCR413, TGFB120, and JUND21, in HCT116 cells [PMC6113222].

Literature search

75 open access papers mention hsa-mir-663a
(535 sentences)

Sequence

1048 reads, 493 reads per million, 76 experiments

ccuuccggcgucccAGGCGGGGCGCCGCGGGACCGCccucgugucuguggcggugggaucccgcggccguguuuuccugguggcccggccaug
....((((.((((((((.((.(((((((((((((((((........).))))).....)))))))).))).))..))))).))))))).....

Structure

-ccuu    c   -     -C  G   -        -----     - ucg 
     ccgg guc ccAGG  GG GCG CCGCGGGA     CCGCc c   u
     |||| ||| |||||  || ||| ||||||||     ||||| |    
     ggcc cgg ggucc  uu ugc ggcgcccu     ggcgg g   g
guacc    -   u     uu  g   c        agggu     u ucu 

Annotation confidence Low

Genome context

chr20: 26208186-26208278 [-]

Disease association

hsa-mir-663a is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-663a

• Accession: MIMAT0003326
• Description: Homo sapiens hsa-miR-663a mature miRNA
• Sequence: 15 - AGGCGGGGCGCCGCGGGACCGC - 36
• Evidence: experimental ; SAGE [1]

References

1. PubMed ID: 16505370
   The colorectal microRNAome
   "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
   "Proc Natl Acad Sci U S A (2006) 103:3687-3692