Stem-loop hsa-mir-449b

Accession

MI0003673

Symbol

HGNC: MIR449B

Description

Homo sapiens hsa-mir-449b precursor miRNA mir-449

Gene
family

RF00711; mir-449

Literature search

83 open access papers mention hsa-mir-449b
(414 sentences)

Sequence

4378 reads, 514 reads per million, 49 experiments

ugaccugaaucagguAGGCAGUGUAUUGUUAGCUGGCugcuugggucaagucagCAGCCACAACUACCCUGCCACUugcuucuggauaaauucuucu
...((.(((.(((((.(((((.(((..(((.(.((((((((.((......))))))))))))))))).)))))))))).))).))............

Structure

---------uga  u   u     A     U   UU   A C        u  gu 
            cc gaa caggu GGCAG GUA  GUU G UGGCugcu gg  c
            || ||| ||||| ||||| |||  ||| | |||||||| ||   
            gg cuu guUCA CCGUC CAU  CAA C ACCGACga cu  a
ucuucuuaaaua  u   c     -     C   --   - -        -  ga 

Annotation confidence High

Genome context

chr5: 55170646-55170742 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-449b

Disease association

hsa-mir-449b is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-449b is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-449b is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-449b-5p

• Accession: MIMAT0003327
• Description: Homo sapiens hsa-miR-449b-5p mature miRNA
• Sequence: 16 - AGGCAGUGUAUUGUUAGCUGGC - 37
• Evidence: experimental ; Microarray [1], RT-PCR [1], SAGE [1], cloned [2]

Mature hsa-miR-449b-3p

• Accession: MIMAT0009203
• Description: Homo sapiens hsa-miR-449b-3p mature miRNA
• Sequence: 55 - CAGCCACAACUACCCUGCCACU - 76
• Evidence: experimental ; 454 [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 19144710
   Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas
   "Zhu JY, Pfuhl T, Motsch N, Barth S, Nicholls J, Grasser F, Meister G"
   "J Virol (2009) 83:3333-3341


3. PubMed ID: 16505370
   The colorectal microRNAome
   "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
   "Proc Natl Acad Sci U S A (2006) 103:3687-3692