miRBase entry: hsa-mir-411

Stem-loop hsa-mir-411

Homo sapiens hsa-mir-411 precursor miRNA
Gene family
MIPF0000126; mir-379

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR411 is a microRNA that has been shown to target Drp1 and is upregulated in DHBE cells compared to NHBE cells [PMC9626984]. Differential miRNA cargo within sEVs containing MIR411 may induce senescence in healthy epithelial cells and could be a potential target for therapeutics in idiopathic pulmonary fibrosis [PMC9930250]. In the context of Alzheimer's disease (AD), MIR411 is downregulated in the cortex of AD patients [PMC7564652]. MIR411 has been previously studied and reported in the brain tissue of AD patients [PMC7564652]. In fibroblasts, MIR411 has higher expression compared to its expression in D492 cells [PMC7308478]. Additionally, MIR411 is downregulated in AF+AVBvsCTL and AFvsCTL analyses [PMC8376273]. MIR411 is part of the miR655 cluster, which includes other miRNAs such as miR134, miR154, and miR655 [PMC10148110]. In colorectal cancer (CRC), MIR411 is one of five microRNAs that can distinguish lymph node metastasis [PMC9614158]. Furthermore, MIR411 is expressed in BMSC-derived exosomes and can modulate the NF-κB pathway to inhibit pro-inflammatory cytokine release [PMC7897935]. Along the Dlk1-Dio3 imprinted domain, which includes Mir136 and Mir127 along Rtl1as, Mir370 along Rian, Mir154 along Mirg, and other miRNAs such as MIR411 are transcribed from the maternal chromosome [PMC3919614]. Finally, a risk-prediction model for lymph node metastasis includes MIR411 as one of five associated microRNAs [PMC8593512].

Literature search
33 open access papers mention hsa-mir-411
(135 sentences)


10840 reads, 140 reads per million, 99 experiments

--------------       ug   a a    A      AUA       - uuu 
              ugguacu  gag g UAGU GACCGU   GCGUACG c   a
              |||||||  ||| | |||| ||||||   ||||||| |   u
              acuauga  cuc C AUCA CUGGCA   UGUAUgc g   c
gagccccuaccuaa       --   C A    C      CAA       a ugu 

Annotation confidence High
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Genome context
chr14: 101023325-101023420 [+]
Clustered miRNAs
11 other miRNAs are < 10 kb from hsa-mir-411
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-411 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-411-5p

Accession MIMAT0003329
Description Homo sapiens hsa-miR-411-5p mature miRNA
Evidence experimental
Microarray [1], RT-PCR [1], SAGE [1], cloned [2]
Database links
Predicted targets

Mature hsa-miR-411-3p

Accession MIMAT0004813
Description Homo sapiens hsa-miR-411-3p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16505370
    The colorectal microRNAome
    "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
    "Proc Natl Acad Sci U S A (2006) 103:3687-3692