Stem-loop hsa-mir-655

Accession

MI0003677

Symbol

HGNC: MIR655

Description

Homo sapiens hsa-mir-655 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR655 is a microRNA that has recently been associated with the regulation of reactive oxygen species (ROS) production, marking the first time it has been linked to oxidative stress [PMC6720387]. This microRNA, along with miR526b, demonstrates increased expression levels during conditions of cellular oxidative stress, suggesting a role in the cellular response to such stress [PMC6720387]. Additionally, MIR655 is implicated in the upregulation of vascular endothelial growth factors (VEGFs) that are known to promote lymphangiogenesis; this process is believed to be induced by certain COX-2/EP4-related microRNAs, including MIR655 [PMC7956318].

Literature search

13 open access papers mention hsa-mir-655
(318 sentences)

Sequence

2165 reads, 45 reads per million, 74 experiments

aacuaugcaaggauauuugaggAGAGGUUAUCCGUGUUAUGUUCgcuucauucaucaugaAUAAUACAUGGUUAACCUCUUUuugaauaucagacuc
...........(((((((((((((((((((.((((((..((((((............))))))..)))))).)))))))))))))))))))......

Structure

aacuaugcaag                   U      UA      cuuca 
           gauauuugaggAGAGGUUA CCGUGU  UGUUCg     u
           ||||||||||||||||||| ||||||  ||||||      
           cuauaaguuUUUCUCCAAU GGUACA  AUAagu     u
-----cucaga                   U      UA      acuac 

Annotation confidence High

Genome context

chr14: 101049550-101049646 [+]

Clustered miRNAs

19 other miRNAs are < 10 kb from hsa-mir-655

Disease association

hsa-mir-655 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-655-3p

• Accession: MIMAT0003331
• Description: Homo sapiens hsa-miR-655-3p mature miRNA
• Sequence: 61 - AUAAUACAUGGUUAACCUCUUU - 82
• Evidence: experimental ; Microarray [1], RT-PCR [1], SAGE [1], cloned [2], Illumina [3]

Mature hsa-miR-655-5p

• Accession: MIMAT0026626
• Description: Homo sapiens hsa-miR-655-5p mature miRNA
• Sequence: 23 - AGAGGUUAUCCGUGUUAUGUUC - 44
• Evidence: experimental ; Illumina [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16505370
   The colorectal microRNAome
   "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
   "Proc Natl Acad Sci U S A (2006) 103:3687-3692


3. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45