miRBase entry: hsa-mir-421

Stem-loop hsa-mir-421

Homo sapiens hsa-mir-421 precursor miRNA
Gene family
MIPF0000098; mir-95

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR421 is a microRNA that has been studied in various diseases, including gastric cancer, colorectal cancer (CRC), breast cancer, vitiligo, and osteogenesis. In gastric cancer patients, the levels of MIR421 in gastric juice were significantly different compared to patients with benign gastric disease [PMC6924079]. In CRC, a model combining the fecal levels of MIR421, MIR27a-3p, and hemoglobin showed improved accuracy in identifying patients with CRC compared to fecal hemoglobin concentration alone [PMC9318064]. MIR421 has been shown to target a binding site in the 3'-UTR of ACE2 transcript and negatively regulate the receptor [PMC7653219]. It has also been implicated in promoting cancer cell proliferation in breast cancer and non-small cell lung cancer [PMC7802300]. In gastrointestinal (GI) cancers, including CRC and gastric cancer, a three-miRNA signature (miGISig) that includes MIR421 has been identified as predictive of GI and clinical outcome [PMC7802300]. Furthermore, MIR421 has been reported to cause the failure of DNA repair by suppressing the expression of ataxia-telangiectasia mutated (ATM), a core component of the DNA repair system [PMC7802300]. Additionally, MIR421 is associated with oxidative stress response in vitiligo and may play a regulatory role in osteogenesis by targeting BMP2 [PMC9313271] [PMC9753082]. In various cancers such as GC, HCC, PCa tumor tissues and nasopharyngeal carcinoma tumor tissues high expression of MIR421 is significantly associated with poor clinical outcomes. However it may play different roles depending on the type of tumor it is expressed on. It acts as an oncomiRNA promoting cell proliferation on GC,HCC PCa tumor tissues but it may play a tumor-suppressor role in prostate cancer cells [PMC6089101].

Literature search
50 open access papers mention hsa-mir-421
(142 sentences)


47199 reads, 455 reads per million, 104 experiments

----g    uu      -    uua            a   aaa 
     caca  guaggc cuca   aauguuuguuga uga   a
     ||||  |||||| ||||   |||||||||||| |||   a
     gugu  cgucCG GGGU   UUACAGACAACU Acu   u
cucua    cu      C    UAA            -   aag 

Annotation confidence High
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Genome context
chrX: 74218377-74218461 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-421
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-421 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-421

Accession MIMAT0003339
Description Homo sapiens hsa-miR-421 mature miRNA
Evidence experimental
Microarray [1], SAGE [1], cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16505370
    The colorectal microRNAome
    "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
    "Proc Natl Acad Sci U S A (2006) 103:3687-3692