Stem-loop ebv-mir-BART4

Accession

MI0003726

Description

Epstein Barr virus ebv-mir-BART4 precursor miRNA

Sequence

uuugguggGACCUGAUGCUGCUGGUGUGCUguaaauaagugccuagCACAUCACGUAGGCACCAGGUGUcaccagg
.(((((((.(((((.((((((((((((((((((......)))..))))))))).))).))).))))).))))))).

Structure

u       G     A   -   -         --   aa 
 uuggugg ACCUG UGC UGC UGGUGUGCU  gua  u
 ||||||| ||||| ||| ||| |||||||||  |||   
 gaccacU UGGAC ACG AUG ACUACACga  cgu  a
g       G     C   G   C         uc   ga 

Annotation confidence Not enough data

Comments

mir-BART4 was discovered independently by two groups. Cai et al. mapped the ends of the mature sequence by cloning [1]. Grundhoff et al confirmed that the 5' arm gives rise to a mature miRNA product, but didnot experimentally determine the extents of that product [2].

Genome context

HHV507799: 139220-139295 [+]

Clustered miRNAs

20 other miRNAs are < 10 kb from ebv-mir-BART4

Disease association

ebv-mir-BART4 is associated with one or more human diseases in the Human microRNA Disease Database

Mature ebv-miR-BART4-5p

• Accession: MIMAT0003412
• Description: Epstein Barr virus ebv-miR-BART4-5p mature miRNA
• Sequence: 9 - GACCUGAUGCUGCUGGUGUGCU - 30
• Evidence: experimental ; cloned [1,3], array [2], Northern [2]

Mature ebv-miR-BART4-3p

• Accession: MIMAT0009204
• Description: Epstein Barr virus ebv-miR-BART4-3p mature miRNA
• Sequence: 47 - CACAUCACGUAGGCACCAGGUGU - 69
• Evidence: experimental ; 454 [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 19144710
   Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas
   "Zhu JY, Pfuhl T, Motsch N, Barth S, Nicholls J, Grasser F, Meister G"
   "J Virol (2009) 83:3333-3341


3. PubMed ID: 16557291
   Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed
   Cai X, Schäfer A, Lu S, Bilello JP, Desrosiers RC, Edwards R, Raab-Traub N, Cullen BR
   PLoS Pathog (2006) 2:e23


4. PubMed ID: 16540699
   A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses
   "Grundhoff A, Sullivan CS, Ganem D"
   "RNA (2006) 12:733-750