miRBase entry: hsa-mir-671

Stem-loop hsa-mir-671

Homo sapiens hsa-mir-671 precursor miRNA
Gene family
MIPF0000358; mir-671

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR671 is a microRNA that has been identified in various studies and has been found to play a role in different biological processes. In one study, six miRNAs, including MIR671, were identified, but only miR1226 showed statistically significant differences [PMC6764711]. Another study found that MIR671 is present in EpCAM-Exos and is one of eight novel miRNAs identified [PMC5137021]. Multiple studies have shown that MIR671, along with other genes such as Lcn2, Cd74, and Cebpd, play a role in the immune response of macrophages and/or microglia as retinal degeneration increases [PMC8362665] [PMC4872275]. Additionally, MIR671 has been found to be involved in regulating extracellular matrix production and acts as a sponge for its target transcript [PMC4872275] [PMC9918958]. In the context of preeclampsia, MIR671 was found to be increased along with other miRNAs associated with various processes such as injury, oxidative stress, inflammation, and hypertension [PMC5933288]. Furthermore, MIR671 was identified as one of the upregulated intragenic miRNAs residing within upregulated genes in non-protein coding regions [PMC5823624]. These findings highlight the diverse roles of MIR671 in different biological contexts.

Literature search
40 open access papers mention hsa-mir-671
(291 sentences)


23353 reads, 373 reads per million, 141 experiments

   ggu aa     ----a    a        A   A      GA           u  ug 
gca   g  cuggc     ggcc ggaagagg GGA GCCCUG  GGGGCUGGAGg ga  g
|||   |  |||||     |||| |||||||| ||| ||||||  ||||||||||| ||  a
cgu   c  gaccg     ccgg cuuucuCC CCU CGGGAC  UCUUGGCCUcc uu  u
   ggu gg     agaug    g        A   -      --           u  ug 

Annotation confidence High
Do you think this miRNA is real?
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr7: 151238421-151238538 [+]

Disease association
hsa-mir-671 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-671-5p

Accession MIMAT0003880
Description Homo sapiens hsa-miR-671-5p mature miRNA
Evidence experimental
cloned [1-2]
Database links
Predicted targets

Mature hsa-miR-671-3p

Accession MIMAT0004819
Description Homo sapiens hsa-miR-671-3p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16954537
    Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
    "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
    "Genome Res (2006) 16:1289-1298