Stem-loop hsa-mir-767

Accession

MI0003763

Symbol

HGNC: MIR767

Description

Homo sapiens hsa-mir-767 precursor miRNA mir-767

Gene
family

RF01033; mir-767

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR767 is a microRNA that has been studied in various contexts. In one study, the level of MIR767 was explored in senescent vascular endothelial cells-derived exosomes and its expression levels were examined after co-culture with skin fibroblasts [PMC9908644]. Additionally, a 214.11-kb duplication in the chromosomal Xq28 region, which includes the GABRA3, MIR105-1, MIR767, and MIR105-2 genes, was identified in a proband via microarray analysis and was inherited from his healthy mother [PMC6894506]. This duplication has been associated with mental development abnormalities [PMC6894506]. In another study comparing miRNA expression levels in PANC-1 cells and hTERT-HPNE cells, it was found that MIR767 showed higher expression levels in PANC-1 cells compared to hTERT-HPNE cells [PMC3849454]. The function of MIR767 is largely unknown at this time [PMC3849454]. Additionally, another miRNA called MIR1269 showed similar expression patterns to MIR767 in the same study. However, its function is also largely unknown except for a potential role during differentiation of human embryonic stem cells [PMC3849454].

Literature search

15 open access papers mention hsa-mir-767
(21 sentences)

Sequence

1986 reads, 325 reads per million, 40 experiments

gcuuuuauauuguagguuuuugcucaUGCACCAUGGUUGUCUGAGCAUGcagcaugcuugUCUGCUCAUACCCCAUGGUUUCUgagcaggaaccuucauugucuacugc
((....(((.((.(((((((((((((...(((((((..((.((((((.((((.....)))).)))))).)).)))))))...))))))))))))).)).))).....))

Structure

  -uuuu   u  u             UGC       UU  C      U    c 
gc     aua ug agguuuuugcuca   ACCAUGG  GU UGAGCA Gcag a
||     ||| || |||||||||||||   |||||||  || |||||| |||| u
cg     ugu ac uccaaggacgagU   UGGUACC  CA ACUCGU Uguu g
  ucauc   u  u             CUU       -C  U      C    c 

Annotation confidence High

Genome context

chrX: 152393421-152393529 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-767

Disease association

hsa-mir-767 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-767-5p

• Accession: MIMAT0003882
• Description: Homo sapiens hsa-miR-767-5p mature miRNA
• Sequence: 27 - UGCACCAUGGUUGUCUGAGCAUG - 49
• Evidence: experimental ; cloned [1]

Mature hsa-miR-767-3p

• Accession: MIMAT0003883
• Description: Homo sapiens hsa-miR-767-3p mature miRNA
• Sequence: 61 - UCUGCUCAUACCCCAUGGUUUCU - 83
• Evidence: experimental ; cloned [1]

References

1. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298