Stem-loop hsa-mir-767

Accession

MI0003763

Symbol

HGNC: MIR767

Description

Homo sapiens hsa-mir-767 precursor miRNA mir-767

Gene
family

RF01033; mir-767

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR767 is a microRNA located within a 214.11-kb duplication on the Xq28 chromosomal region, which has been associated with abnormal mental development [PMC6894506]. This duplication, which also includes the GABRA3, MIR105-1, and MIR105-2 genes, was found in both a proband with mental development issues and his healthy mother [PMC6894506]. In the context of cellular interactions, MIR767 has been identified in exosomes derived from senescent vascular endothelial cells and has shown altered expression levels when these exosomes are co-cultured with skin fibroblasts [PMC9908644]. Furthermore, differential expression of MIR767 has been observed in cancer research; it is notably absent in hTERT-HPNE cells but highly expressed in PANC-1 cancer cells [PMC3849454]. Despite these findings, the specific functions of MIR767 remain largely unexplored [PMC3849454].

Literature search

15 open access papers mention hsa-mir-767
(21 sentences)

Sequence

1986 reads, 325 reads per million, 40 experiments

gcuuuuauauuguagguuuuugcucaUGCACCAUGGUUGUCUGAGCAUGcagcaugcuugUCUGCUCAUACCCCAUGGUUUCUgagcaggaaccuucauugucuacugc
((....(((.((.(((((((((((((...(((((((..((.((((((.((((.....)))).)))))).)).)))))))...))))))))))))).)).))).....))

Structure

  -uuuu   u  u             UGC       UU  C      U    c 
gc     aua ug agguuuuugcuca   ACCAUGG  GU UGAGCA Gcag a
||     ||| || |||||||||||||   |||||||  || |||||| |||| u
cg     ugu ac uccaaggacgagU   UGGUACC  CA ACUCGU Uguu g
  ucauc   u  u             CUU       -C  U      C    c 

Annotation confidence High

Genome context

chrX: 152393421-152393529 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-767

Disease association

hsa-mir-767 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-767-5p

• Accession: MIMAT0003882
• Description: Homo sapiens hsa-miR-767-5p mature miRNA
• Sequence: 27 - UGCACCAUGGUUGUCUGAGCAUG - 49
• Evidence: experimental ; cloned [1]

Mature hsa-miR-767-3p

• Accession: MIMAT0003883
• Description: Homo sapiens hsa-miR-767-3p mature miRNA
• Sequence: 61 - UCUGCUCAUACCCCAUGGUUUCU - 83
• Evidence: experimental ; cloned [1]

References

1. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298