miRBase entry: hsa-mir-454

Stem-loop hsa-mir-454

Homo sapiens hsa-mir-454 precursor miRNA
Gene family
MIPF0000174; mir-454

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR454 is a microRNA that has been studied in various contexts, including colorectal tissues, gastric cancer, lymphoma, and frailty. In colorectal tissues, the stability of MIR454 and other miRNAs was assessed to determine appropriate normalizers for different study cohorts [PMC2873395]. However, MIR454 was subsequently excluded from an in vitro study [PMC6659797]. The MIR130 family, which includes MIR454, shares a common seed sequence and can target a common sequence [PMC6659797]. Remarkable correlations were observed between various combinations of MIR130 family members and BHLHE40/41, except for those involving MIR454 [PMC6659797]. In gastric cancer tissues, overexpression of MIR454 was associated with advanced clinical stage and poor prognosis for patients [PMC7185177]. In lymphoma patients, miR21, miR130b, miR155 were upregulated or downregulated along with other miRNAs including MIR454 between diagnosis/remission or relapse/remission [PMC7782091]. In prostate cancer (miR1256), bladder tumors (MIR454), and breast cancer (miR548), different miRNAs including MIR454 have been implicated in their pathogenesis [PMC7920560]. Furthermore,MiR187 has been studied in the context of glioblastoma[PMC4938405].
MIR454 has also been implicated in the regulation of genes involved in tumour progression and metastasis[ PMC8243332]..
In frailty research,Mir-1251 is associated with frailty[ PMC8169753]..
In summary,Mir-1251 is associated with frailty[ PMC8169753]..'>PMC8169753]..
Overall,Mir-1251 is associated with frailty[ PMC8169753].
In glioblastoma,the levels of several microRNAs including Mir-454 are altered[PMC8470251].

Literature search
39 open access papers mention hsa-mir-454
(284 sentences)


55773 reads, 604 reads per million, 117 experiments

u       ----  --a      c            ---         ----   --U     g 
 cuguuua    uc   ccagau cuagaACCCUAU   CAAUAUUGU    CUC   GCugu u
 |||||||    ||   |||||| ||||||||||||   |||||||||    |||   |||||  
 gacgggu    ag   gguuug gguuuUGGGAUA   GUUAUAACG    gag   ugaua a
g       aaca  aaa      u            UUC         UGAU   ucu     a 

Annotation confidence High
Do you think this miRNA is real?
The mature miRNA sequences were named miR-454-5p and miR-454-3p in [1] and here. Landgraf et al. showed that the 3' product is the predominant one [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr17: 59137758-59137872 [-]

Disease association
hsa-mir-454 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-454-5p

Accession MIMAT0003884
Description Homo sapiens hsa-miR-454-5p mature miRNA
Evidence experimental
cloned [1-2]
Database links
Predicted targets

Mature hsa-miR-454-3p

Accession MIMAT0003885
Description Homo sapiens hsa-miR-454-3p mature miRNA
Evidence experimental
cloned [1-2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16954537
    Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
    "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
    "Genome Res (2006) 16:1289-1298