miRBase entry: ebv-mir-BART19

Stem-loop ebv-mir-BART19

Accession

MI0004992

Description

Epstein Barr virus ebv-mir-BART19 precursor miRNA

Sequence

guauccguguccugacaACAUUCCCCGCAAACAUGACAUGgguuaauuuaaacaugUUUUGUUUGCUUGGGAAUGCUcuuagggccuggaagc
((.((((.(((((((...(((((((.(((((((.((((((..(......)..)))))).)))))))..)))))))...))))))).)))).))

Structure

  a    u       caA       -C       U      gg ua 
gu uccg guccuga   CAUUCCC  GCAAACA GACAUG  u  a
|| |||| |||||||   |||||||  ||||||| ||||||  |   
cg aggu cgggauu   GUAAGGG  CGUUUGU UUguac  a  u
  a    c       cUC       UU       U      aa uu

Annotation confidence Not enough data

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Comments

The arm of the precursor miRNA giving rise to the mature sequence was verified using microarray hybridisation and Northern blot, but the extents of the mature miRNA shown here are predicted and not experimentally determined [1]. This sequence was named miR-BART17 by Grundhoff et al [1]. The mature miRNA names and sequences reflect cloning frequencies from Landgraf et al. [2]. The ends of the miRNA may be offset with respect to previous annotations.

Genome context

HHV507799: 148198-148290 [+]

Clustered miRNAs

21 other miRNAs are < 10 kb from ebv-mir-BART19

Name	Accession	Chromosome	Start	End	Strand	Confidence

Disease association

ebv-mir-BART19 is associated with one or more human diseases in the Human microRNA Disease Database

Disease	Description	Category	PubMed ID

Database links

Mature ebv-miR-BART19-5p

Accession	MIMAT0004836
Description	Epstein Barr virus ebv-miR-BART19-5p mature miRNA
Sequence	18 - ACAUUCCCCGCAAACAUGACAUG - 40
Evidence	experimental cloned [2]

Mature ebv-miR-BART19-3p

Accession	MIMAT0003718
Description	Epstein Barr virus ebv-miR-BART19-3p mature miRNA
Sequence	57 - UUUUGUUUGCUUGGGAAUGCU - 77
Evidence	experimental array [1], Northern [1], cloned [2]

References

PubMed ID: 17604727
A mammalian microRNA expression atlas based on small RNA library sequencing
"Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
"Cell (2007) 129:1401-1414

PubMed ID: 16540699
A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses
"Grundhoff A, Sullivan CS, Ganem D"
"RNA (2006) 12:733-750