miRBase entry: bta-let-7c

Stem-loop bta-let-7c

Bos taurus bta-let-7c precursor miRNA
Gene family
MIPF0000002; let-7

Caution, this is an AI generated summary based on literature. This may have errors. ?

Bta-let-7c is a microRNA that has been observed in both placental exosomes and non-pregnant exosomes, with significant differences in expression compared to other bta-let-7 microRNAs [PMC5999645]. Overexpression of bta-let-7c has been shown to decrease the expression of NRAS and downregulate LPS-induced proinflammatory cytokines [PMC5999645]. Bta-let-7c, along with bta-let-7a-5p and bta-miR-196b, may regulate glycerophospholipid metabolism by inhibiting the expression of enzymes involved in triglyceride synthesis and degradation [PMC5341059]. Bta-miR-148a, bta-miR30a-5p, bta-miR30d, and bta-miR30d were found to be among the top 10 expressed miRNAs in different species of milk [PMC7191744]. Bta-miR127 and bta-let7c have been implicated in the regulation of inflammatory response [PMC4617749]. Bta-miR127 is known to regulate a specific gene along with btalet7c [PMC7937231]. Btale t 7c was found to be differentially expressed in CoPS vs. H comparison [PMC7937231]. In different tissues such as ovary and testis, several miRNAs including btamir143, btamir378, btale t 7f were found to be dominant expressed miRNAs with more than 100000 reads [PMC3164151]. In Holstein cattle several miRNAs including btamir143 were found to be most abundant [PMC5410099]. The role of target interleukin1 (IL1) may be affected by btamir181d and btale t 7c in regulating the mammary gland function of dairy cows [PMC9686552].

Literature search
52 open access papers mention bta-let-7c
(234 sentences)


243137 reads, 1399 reads per million, 76 experiments

  a      uU   G   U             ua  g ua  c 
gc uccggg  GAG UAG AGGUUGUAUGGUU  ga u  ca  
|| ||||||  ||| ||| |||||||||||||  || |  || c
cg agguuc  uuc auc uccaacaugucaa  uu a  gu  
  -      cu   g   u             --  g gg  c 

Annotation confidence High
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Genome context
chr1: 19984844-19984927 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from bta-let-7c
Name Accession Chromosome Start End Strand Confidence

Database links

Mature bta-let-7c

Accession MIMAT0004332
Description Bos taurus bta-let-7c mature miRNA
Evidence experimental
cloned [1]


  1. PubMed ID: 17306260
    Identification and characterization of microRNAs from the bovine adipose tissue and mammary gland
    "Gu Z, Eleswarapu S, Jiang H"
    "FEBS Lett (2007) 581:981-988