Accession
MI0005458
Description
Bos taurus
bta-mir-15a precursor miRNA mir-15
Gene
family?
family?
RF00455;
mir-15
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Bovine microRNA bta-mir-15a, a highly abundant miRNA in X sperm, has been implicated in various biological processes in dairy cows [PMC7505075]. It is significantly upregulated in mastitis-related conditions [PMC6107498] and has been suggested as a novel regulator promoting lactation in mammary epithelial cells [PMC6268530]. Despite its presence, bta-mir-15a expression levels do not significantly differ between B cells of BLV-infected and uninfected cattle [PMC8432782]. It is down-regulated upon data normalization, indicating its expression is sensitive to analytical methods [PMC3589390]. Bta-mir-15a has been shown to inhibit the expression of the growth hormone receptor (GHR) protein at the translational level, indirectly affecting casein synthesis, although the underlying mechanisms remain to be elucidated [PMC6268530]. The miRNA also influences cell proliferation and viability in mammary epithelial cells by targeting GHR gene expression; overexpression of bta-mir-15a reduces GHR and casein levels as well as cell viability, while inhibition of bta-mir-15a increases them [PMC6268530]. These findings suggest that bta-mir-15a plays a critical role in mammary gland development and lactation by regulating GHR mRNA and protein levels [PMC6268530], potentially affecting dairy cow productivity.
Literature search
17 open access papers mention bta-mir-15a
(31 sentences)
(31 sentences)
Sequence
20653
reads,
355
reads per million, 74 experiments
ccuuggaguaaagUAGCAGCACAUAAUGGUUUGUggauuuugaaaaggugcaggccauauugugcugccucaaaaauacaagg
(((((.......(..((((((((..((((((((((.............))))))))))..))))))))..).......)))))
(((((.......(..((((((((..((((((((((.............))))))))))..))))))))..).......)))))
Structure
gaguaaa UA UA gauuu
ccuug g GCAGCACA AUGGUUUGUg u
||||| | |||||||| |||||||||| g
ggaac c cgucgugu uaccggacgu a
auaaaaa uc ua ggaaa
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr12: 19660532-19660614 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from bta-mir-15a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Database links
Mature bta-miR-15a
| Accession | MIMAT0004334 |
| Description | Bos taurus bta-miR-15a mature miRNA |
| Sequence | 14 - UAGCAGCACAUAAUGGUUUGU - 34 |
| Evidence |
experimental
cloned [1] |
References
|
