miRBase entry: hsa-mir-889

Stem-loop hsa-mir-889


Accession
MI0005540
Symbol
HGNC: MIR889
Description
Homo sapiens hsa-mir-889 precursor miRNA mir-889
Gene
family?
RF04293; mir-889

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR889 is a microRNA (miRNA) that is part of the miR655 miRNA cluster, which includes a total of 20 miRNAs, with expression data available for nine of these, including MIR889 [PMC7465874]. This particular miRNA has been identified as upregulated in patients who developed hepatocellular carcinoma (HCC) in the context of hepatitis C virus (HCV) infections and chronic HCV complications [PMC9495750]. Additionally, MIR889 has been found to influence the expression of DAB2IP, which in turn can downregulate immune infiltration by B cells and CD8+ T cells within the colorectal cancer microenvironment [PMC10114864]. This suggests that MIR889 may play a role in immune evasion by cancer cells. Furthermore, MIR889 is one of the most differentially expressed (DE) miRNAs identified in a genomic region associated with disease conditions in dogs according to research mapping to the canine reference genome CanFam3.1 [PMC8376273].

Literature search
10 open access papers mention hsa-mir-889
(21 sentences)

Sequence

6883 reads, 80 reads per million, 77 experiments
gugcuuaaagAAUGGCUGUCCGUAGUAUGGUCucuauauuuaugaugaUUAAUAUCGGACAACCAUUGUuuuaguaucc
(((((.(((.(((((.((((((..((.(((((((.........)).)))))))..)))))).))))).))).)))))..

Structure
--     u   g     C      UA  A     -  uau 
  gugcu aaa AAUGG UGUCCG  GU UGGUC uc   a
  ||||| ||| ||||| ||||||  || ||||| ||   u
  uauga uuU UUACC ACAGGC  UA AUUag ag   u
cc     u   G     A      UA  -     u  uau 


Annotation confidence High
Do you think this miRNA is real?

Genome context
chr14: 101047901-101047979 [+]
Clustered miRNAs
19 other miRNAs are < 10 kb from hsa-mir-889
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-889 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-889-3p

Accession MIMAT0004921
Description Homo sapiens hsa-miR-889-3p mature miRNA
Sequence 49 - UUAAUAUCGGACAACCAUUGU - 69
Evidence experimental
cloned [1], Illumina [2]
Database links
Predicted targets

Mature hsa-miR-889-5p

Accession MIMAT0026719
Description Homo sapiens hsa-miR-889-5p mature miRNA
Sequence 11 - AAUGGCUGUCCGUAGUAUGGUC - 32
Evidence experimental
Illumina [2]

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45