Accession
MI0005540
Symbol
HGNC:
MIR889
Description
Homo sapiens
hsa-mir-889 precursor miRNA mir-889
Gene
family?
family?
RF04293;
mir-889
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR889 is a microRNA (miRNA) that is part of the miR655 miRNA cluster, which includes a total of 20 miRNAs, with expression data available for nine of these, including MIR889 [PMC7465874]. This particular miRNA has been identified as upregulated in patients who developed hepatocellular carcinoma (HCC) in the context of hepatitis C virus (HCV) infections and chronic HCV complications [PMC9495750]. Additionally, MIR889 has been found to influence the expression of DAB2IP, which in turn can downregulate immune infiltration by B cells and CD8+ T cells within the colorectal cancer microenvironment [PMC10114864]. This suggests that MIR889 may play a role in immune evasion by cancer cells. Furthermore, MIR889 is one of the most differentially expressed (DE) miRNAs identified in a genomic region associated with disease conditions in dogs according to research mapping to the canine reference genome CanFam3.1 [PMC8376273].
Literature search
10 open access papers mention hsa-mir-889
(21 sentences)
(21 sentences)
Sequence
6883
reads,
80
reads per million, 77 experiments
gugcuuaaagAAUGGCUGUCCGUAGUAUGGUCucuauauuuaugaugaUUAAUAUCGGACAACCAUUGUuuuaguaucc
(((((.(((.(((((.((((((..((.(((((((.........)).)))))))..)))))).))))).))).)))))..
(((((.(((.(((((.((((((..((.(((((((.........)).)))))))..)))))).))))).))).)))))..
Structure
-- u g C UA A - uau gugcu aaa AAUGG UGUCCG GU UGGUC uc a ||||| ||| ||||| |||||| || ||||| || u uauga uuU UUACC ACAGGC UA AUUag ag u cc u G A UA - u uau
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr14: 101047901-101047979 [+]
Clustered miRNAs
19 other miRNAs are < 10 kb from hsa-mir-889
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-889 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-889-3p
| Accession | MIMAT0004921 |
| Description | Homo sapiens hsa-miR-889-3p mature miRNA |
| Sequence | 49 - UUAAUAUCGGACAACCAUUGU - 69 |
| Evidence |
experimental
cloned [1], Illumina [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-889-5p
| Accession | MIMAT0026719 |
| Description | Homo sapiens hsa-miR-889-5p mature miRNA |
| Sequence | 11 - AAUGGCUGUCCGUAGUAUGGUC - 32 |
| Evidence |
experimental
Illumina [2] |
References
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