Stem-loop hsa-mir-147b

Accession

MI0005544

Symbol

HGNC: MIR147B

Description

Homo sapiens hsa-mir-147b precursor miRNA mir-147

Gene
family

RF00693; mir-147

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

Hsa-mir-147b is a microRNA that plays a significant role in the molecular landscape of rectum cancer, as its expression is characteristic of this malignancy [PMC10152154]. This microRNA's expression is negatively influenced by bile acids in the context of right-sided colon tumors, particularly when the CHRM3 gene is present [PMC10152154]. In a comparative study across different populations, hsa-mir-147b was identified as one of six effective microRNA pairings in India that are potentially involved in the interaction with viral SARS-CoV-2 miRNAs [PMC7395633]. This suggests that hsa-mir-147b may have broader implications beyond rectum cancer, possibly playing a role in viral interactions as well [PMC7395633].

Literature search

46 open access papers mention hsa-mir-147b
(358 sentences)

Sequence

1649 reads, 208 reads per million, 88 experiments

uauaaaucuagUGGAAACAUUUCUGCACAAACUagauucuggacaccaGUGUGCGGAAAUGCUUCUGCUacauuuuuagg
((.((((.((((((((.((((((((((((.........((((...)))))))))))))))).)))))))).)))).))..

Structure

--  u    c        A            AACUagauu    a 
  ua aaau uagUGGAA CAUUUCUGCACA         cugg  
  || |||| |||||||| ||||||||||||         |||| c
  au uuua aUCGUCUU GUAAAGGCGUGU         Gacc  
gg  u    c        C            ---------    a 

Annotation confidence High

Genome context

chr15: 45433050-45433129 [+]

Disease association

hsa-mir-147b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-147b-3p

• Accession: MIMAT0004928
• Description: Homo sapiens hsa-miR-147b-3p mature miRNA
• Sequence: 49 - GUGUGCGGAAAUGCUUCUGCU - 69
• Evidence: experimental ; cloned [1]

Mature hsa-miR-147b-5p

• Accession: MIMAT0037331
• Description: Homo sapiens hsa-miR-147b-5p mature miRNA
• Sequence: 12 - UGGAAACAUUUCUGCACAAACU - 33
• Evidence: not_experimental

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414