Stem-loop hsa-mir-744

Accession

MI0005559

Symbol

HGNC: MIR744

Description

Homo sapiens hsa-mir-744 precursor miRNA mir-744

Gene
family

RF00936; mir-744

Literature search

47 open access papers mention hsa-mir-744
(449 sentences)

Sequence

159015 reads, 697 reads per million, 134 experiments

uugggcaaggUGCGGGGCUAGGGCUAACAGCAgucuuacugaagguuuccuggaaaccacgcacaugCUGUUGCCACUAACCUCAACCUuacucgguc
(((((.(((((..((((.((((((.(((((((...........((((((...)))))).......)))))))))).))).)))).))))).)))))..

Structure

--     c     GC    C   -   U       gucuuacugaa      c 
  uuggg aaggU  GGGG UAG GGC AACAGCA           gguuuc  
  ||||| |||||  |||| ||| ||| |||||||           |||||| u
  ggcuc uUCCA  CUCC AUC CCG UUGUCgu           ccaaag  
cu     a     -A    A   A   -       ----acacgca      g 

Annotation confidence High

Comments

This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context

chr17: 12081899-12081996 [+]

Disease association

hsa-mir-744 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-744-5p

• Accession: MIMAT0004945
• Description: Homo sapiens hsa-miR-744-5p mature miRNA
• Sequence: 11 - UGCGGGGCUAGGGCUAACAGCA - 32
• Evidence: experimental ; cloned [2]

Mature hsa-miR-744-3p

• Accession: MIMAT0004946
• Description: Homo sapiens hsa-miR-744-3p mature miRNA
• Sequence: 68 - CUGUUGCCACUAACCUCAACCU - 89
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298