Accession
MI0005561
Symbol
HGNC:
MIR877
Description
Homo sapiens
hsa-mir-877 precursor miRNA mir-877
Gene
family?
family?
RF00912;
mir-877
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
hsa-mir-877 is a microRNA that has been implicated in various biological processes and diseases, including acting as an oncogene in gastric cancer [PMC7794682]. It is one of the most abundant miRNAs associated with high-density lipoprotein (HDL) in normal subjects, which suggests a potential role in lipid metabolism or cardiovascular health [PMC3074610]. Additionally, hsa-mir-877 has been identified as upregulated in nonresponder samples of both lung squamous cell carcinoma (LUSC) and head and neck squamous cell carcinoma (HNSC), suggesting a possible involvement in cancer progression or response to therapy [PMC7794682]. Interestingly, hsa-mir-877 is listed among both upregulated and downregulated miRNAs across various studies, indicating complex regulatory roles that may be context-dependent [PMC6921333]. However, it has not been confirmed as a potential endogenous control gene for expression studies due to its relatively uniform expression among candidate reference genes, as other genes were found to be more uniformly expressed [PMC3531299].
Literature search
31 open access papers mention hsa-mir-877
(62 sentences)
(62 sentences)
Sequence
10072
reads,
170
reads per million, 97 experiments
GUAGAGGAGAUGGCGCAGGGgacacgggcaaagacuuggggguuccugggacccucagacgugugUCCUCUUCUCCCUCCUCCCAG
...((((((..((.(.((((((((((.(.......((((((((((...)))))))))).).)))))))))).).))))))))....
...((((((..((.(.((((((((((.(.......((((((((((...)))))))))).).)))))))))).).))))))))....
Structure
-GUA AU C C g caaagac c
GAGGAG GG G AGGGgacacg g uuggggguuc
|||||| || | |||||||||| | |||||||||| u
CUCCUC CC C UCUCCUgugu c gacucccagg
GACC -- U U g ------a g
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].
Genome context
chr6: 30584332-30584417 [+]
Disease association
hsa-mir-877 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-877-5p
| Accession | MIMAT0004949 |
| Description | Homo sapiens hsa-miR-877-5p mature miRNA |
| Sequence | 1 - GUAGAGGAGAUGGCGCAGGG - 20 |
| Evidence |
experimental
cloned [1-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-877-3p
| Accession | MIMAT0004950 |
| Description | Homo sapiens hsa-miR-877-3p mature miRNA |
| Sequence | 66 - UCCUCUUCUCCCUCCUCCCAG - 86 |
| Evidence |
experimental
cloned [1-3] |
| Database links |
|
| Predicted targets |
|
References
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