Stem-loop hsa-mir-877

Accession

MI0005561

Symbol

HGNC: MIR877

Description

Homo sapiens hsa-mir-877 precursor miRNA mir-877

Gene
family

RF00912; mir-877

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

hsa-mir-877 is a microRNA that has been implicated in various biological processes and diseases, including acting as an oncogene in gastric cancer [PMC7794682]. It is one of the most abundant miRNAs associated with high-density lipoprotein (HDL) in normal subjects, which suggests a potential role in lipid metabolism or cardiovascular health [PMC3074610]. Additionally, hsa-mir-877 has been identified as upregulated in nonresponder samples of both lung squamous cell carcinoma (LUSC) and head and neck squamous cell carcinoma (HNSC), suggesting a possible involvement in cancer progression or response to therapy [PMC7794682]. Interestingly, hsa-mir-877 is listed among both upregulated and downregulated miRNAs across various studies, indicating complex regulatory roles that may be context-dependent [PMC6921333]. However, it has not been confirmed as a potential endogenous control gene for expression studies due to its relatively uniform expression among candidate reference genes, as other genes were found to be more uniformly expressed [PMC3531299].

Literature search

31 open access papers mention hsa-mir-877
(62 sentences)

Sequence

10072 reads, 83 reads per million, 97 experiments

GUAGAGGAGAUGGCGCAGGGgacacgggcaaagacuuggggguuccugggacccucagacgugugUCCUCUUCUCCCUCCUCCCAG
...((((((..((.(.((((((((((.(.......((((((((((...)))))))))).).)))))))))).).))))))))....

Structure

-GUA      AU  C C          g caaagac          c 
    GAGGAG  GG G AGGGgacacg g       uuggggguuc  
    ||||||  || | |||||||||| |       |||||||||| u
    CUCCUC  CC C UCUCCUgugu c       gacucccagg  
GACC      --  U U          g ------a          g 

Annotation confidence Medium

Comments

This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context

chr6: 30584332-30584417 [+]

Disease association

hsa-mir-877 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-877-5p

• Accession: MIMAT0004949
• Description: Homo sapiens hsa-miR-877-5p mature miRNA
• Sequence: 1 - GUAGAGGAGAUGGCGCAGGG - 20
• Evidence: experimental ; cloned [1-3]

Mature hsa-miR-877-3p

• Accession: MIMAT0004950
• Description: Homo sapiens hsa-miR-877-3p mature miRNA
• Sequence: 66 - UCCUCUUCUCCCUCCUCCCAG - 86
• Evidence: experimental ; cloned [1-3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298


3. PubMed ID: 17964270
   Mammalian mirtron genes
   "Berezikov E, Chung WJ, Willis J, Cuppen E, Lai EC"
   "Mol Cell (2007) 28:328-336