Stem-loop hsa-mir-543

Accession

MI0005565

Symbol

HGNC: MIR543

Description

Homo sapiens hsa-mir-543 precursor miRNA mir-329

Gene
family

RF04295; mir-329

Literature search

25 open access papers mention hsa-mir-543
(50 sentences)

Sequence

3721 reads, 17 reads per million, 68 experiments

uacuuaaugagaaguugcccguguuuuuuucgcuuuauuugugacgAAACAUUCGCGGUGCACUUCUUuuucaguauc
((((.((.(((((((.(((((((..(.((((((.........).))))).)..))))).))))))))).)).))))..

Structure

--    u  u       u  -     uu u     - uuu 
  uacu aa gagaagu gc ccgug  u uuucg c   a
  |||| || ||||||| || |||||  | ||||| |   u
  auga uu UUCUUCA CG GGCGC  A AAAgc g   u
cu    c  u       -  U     UU C     a ugu 

Annotation confidence Not enough data

Comments

This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression has been independently confirmed in mouse and rat [2].

Genome context

chr14: 101031987-101032064 [+]

Clustered miRNAs

18 other miRNAs are < 10 kb from hsa-mir-543

Disease association

hsa-mir-543 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-543

• Accession: MIMAT0004954
• Description: Homo sapiens hsa-miR-543 mature miRNA
• Sequence: 47 - AAACAUUCGCGGUGCACUUCUU - 68
• Evidence: experimental ; RAKE [1]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298