Stem-loop hsa-mir-374b

Accession

MI0005566

Symbol

HGNC: MIR374B

Description

Homo sapiens hsa-mir-374b precursor miRNA

Literature search

60 open access papers mention hsa-mir-374b
(150 sentences)

Sequence

260462 reads, 720 reads per million, 144 experiments

acucggauggAUAUAAUACAACCUGCUAAGUGuccuagcaCUUAGCAGGUUGUAUUAUCAUUguccgugucu
((.(((((((..(((((((((((((((((((((....)))))))))))))))))))))..))))))).))..

Structure

--  u       AU                     c 
  ac cggaugg  AUAAUACAACCUGCUAAGUGu c
  || |||||||  |||||||||||||||||||||  
  ug gccugUU  UAUUAUGUUGGACGAUUCacg u
uc  u       AC                     a 

Annotation confidence High

Comments

This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context

chrX: 74218547-74218618 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-374b

Disease association

hsa-mir-374b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-374b-5p

• Accession: MIMAT0004955
• Description: Homo sapiens hsa-miR-374b-5p mature miRNA
• Sequence: 11 - AUAUAAUACAACCUGCUAAGUG - 32
• Evidence: experimental ; cloned [2-3]

Mature hsa-miR-374b-3p

• Accession: MIMAT0004956
• Description: Homo sapiens hsa-miR-374b-3p mature miRNA
• Sequence: 41 - CUUAGCAGGUUGUAUUAUCAUU - 62
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298