Stem-loop hsa-mir-374b

Accession

MI0005566

Symbol

HGNC: MIR374B

Description

Homo sapiens hsa-mir-374b precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR374B is a microRNA that has been studied in various contexts. It has been found that the expression of MIR374B is significantly attenuated in primed mesenchymal stem cells (MSCs) compared to naïve MSCs [PMC9509608]. In a network analysis, it was revealed that MIR374B, along with miR-944 and miR-374a, has a regulatory effect on the expression of chemokines such as Cxcl1, Ccl2, and Ccl7 [PMC5712098]. These microRNAs may be associated with the development of autoimmune-mediated arthritis by targeting these chemokines [PMC5712098]. MIR374B has also been found to be overexpressed in B cells in the Chinese population and has an inhibitory effect on chaperone proteins and suppressor genes, leading to increased B-cell proliferation and higher serum concentrations of poorly galactosylated IgA1 [PMC6834307]. In cancer research, it has been shown that MIR374B can directly target PD-1 and partially restore the function of exhausted T cells [PMC6833224]. Additionally, MIR374B levels were found to be low in atheroprotected sites but increased in endothelial cells at atheroprone regions [PMC6590197]. Furthermore, MIR374B has been associated with P-phase and improved survival with regorafenib treatment [PMC7376782] [PMC9589420]. In bladder cancer, MIR374B targets genes involved in cellular migration and invasion [PMC7783806]. Lastly, it was observed that MIR374B expression is significantly downregulated in Han Chinese individuals compared to Uyghurs in healthy skin samples [PMC7783806].

Literature search

60 open access papers mention hsa-mir-374b
(150 sentences)

Sequence

261515 reads, 1430 reads per million, 144 experiments

acucggauggAUAUAAUACAACCUGCUAAGUGuccuagcaCUUAGCAGGUUGUAUUAUCAUUguccgugucu
((.(((((((..(((((((((((((((((((((....)))))))))))))))))))))..))))))).))..

Structure

--  u       AU                     c 
  ac cggaugg  AUAAUACAACCUGCUAAGUGu c
  || |||||||  |||||||||||||||||||||  
  ug gccugUU  UAUUAUGUUGGACGAUUCacg u
uc  u       AC                     a 

Annotation confidence High

Comments

This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context

chrX: 74218547-74218618 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-374b

Disease association

hsa-mir-374b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-374b-5p

• Accession: MIMAT0004955
• Description: Homo sapiens hsa-miR-374b-5p mature miRNA
• Sequence: 11 - AUAUAAUACAACCUGCUAAGUG - 32
• Evidence: experimental ; cloned [2-3]

Mature hsa-miR-374b-3p

• Accession: MIMAT0004956
• Description: Homo sapiens hsa-miR-374b-3p mature miRNA
• Sequence: 41 - CUUAGCAGGUUGUAUUAUCAUU - 62
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298