Accession
MI0006272
Symbol
HGNC:
MIR1179
Description
Homo sapiens
hsa-mir-1179 precursor miRNA mir-1179
Gene
family?
family?
RF03469;
mir-1179
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR1179 is a microRNA implicated in the regulation of thyroid-stimulating hormone (TSH), with a notable association signal identified in genetic studies (P = 2.89×10−10) [PMC3567175]. Although it is not highly represented in the thyroid, it is one of several novel loci that have been linked to TSH regulation, suggesting a potential role in thyroid function [PMC3567175]. The TSH-elevating allele at the MIR1179 locus also appears to be correlated with decreasing levels of free thyroxine (FT4), indicating a possible influence on thyroid hormone synthesis or secretion [PMC3567175]. The biological relevance of MIR1179 has been further highlighted by experiments showing that biotin-labeled hsa-miR-1179 probes can enrich specific mRNA targets, suggesting that MIR1179 may have functional interactions with other genes or transcripts [PMC8716807]. Additionally, MIR1179 expression has been found to be up-regulated in non-functioning adenomas due to lower methylation rates, which may contribute to the pathophysiology of these adenomas [PMC7652879]. However, further research is necessary to confirm these findings and elucidate the precise biological mechanisms by which MIR1179 influences TSH levels and thyroid function [PMC3567175]. Biological targets for MIR1179 have been validated using bioinformatics tools such as TargetScan, providing a foundation for future studies on its role and interactions within cellular pathways [PMC8572446].
Literature search
3 open access papers mention hsa-mir-1179
(5 sentences)
(5 sentences)
Sequence
736
reads,
25
reads per million, 59 experiments
ggcuggaaaggaagAAGCAUUCUUUCAUUGGUUGGuguguauugccuugucaaccaauaagaggaugccauuuauccuuuucugacuagcu
((((((((((((.((((((((((((.(((((((((...(......)...))))))))).)))))))))..))).)))))).....))))))
((((((((((((.((((((((((((.(((((((((...(......)...))))))))).)))))))))..))).)))))).....))))))
Structure
----- a -- C ugu ua
ggcugg aaagga gAA GCAUUCUUU AUUGGUUGG g u
|||||| |||||| ||| ||||||||| ||||||||| |
ucgauc uuuccu uuu cguaggaga uaaccaacu c u
agucu a ac a guu cg
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr15: 88608107-88608197 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-1179
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-1179 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-1179
| Accession | MIMAT0005824 |
| Description | Homo sapiens hsa-miR-1179 mature miRNA |
| Sequence | 15 - AAGCAUUCUUUCAUUGGUUGG - 35 |
| Evidence |
experimental
cloned [1] |
| Database links |
|
| Predicted targets |
|
References
|
