Stem-loop hsa-mir-1290

Accession

MI0006352

Symbol

HGNC: MIR1290

Description

Homo sapiens hsa-mir-1290 precursor miRNA mir-1290

Gene
family

RF03650; mir-1290

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR1290 is a microRNA implicated in various human tumors, functioning as an oncoMiR by regulating gene expression post-transcriptionally [PMC5604572]. It is transcribed from a gene on chromosome 1p36.13 and has been studied for its role in tumorigenesis, including melanoma [PMC8740132], [PMC5604572]. In melanoma, MIR1290 is upregulated in primary tissues and has been shown to inhibit autophagy by targeting BECN1, a key autophagic gene [PMC5604572]. The inhibition of MIR1290 leads to increased BECN1 expression and autophagy induction, suggesting a potential therapeutic strategy for melanoma treatment by downregulating MIR1290 to enhance autophagy [PMC5604572], [PMC9048552]. Additionally, MIR1290 has diagnostic potential as it differentiates pancreatic ductal adenocarcinoma from pancreatic neuroendocrine tumors with high accuracy and may serve as an early diagnostic marker for necrotizing enterocolitis with high sensitivity and specificity [PMC9554633], [PMC9523100]. Furthermore, it is differentially expressed in exosomal miRNAs from various body fluids, indicating its potential as a circulating biomarker for diseases like colorectal adenoma and high-grade serous ovarian cancer [PMC8116025], [PMC8080718].

Literature search

40 open access papers mention hsa-mir-1290
(195 sentences)

Sequence

270 reads, 373 reads per million, 30 experiments

gagcgucacguugacacucaaaaaguuucagauuuuggaacauuucggauuuUGGAUUUUUGGAUCAGGGAugcucaa
(((((((.(.((((...(((((((..((((((.((((((....)))))).))))))))))))).))))))))))))..

Structure

--       a g    cac       gu      u      a 
  gagcguc c uuga   ucaaaaa  uucaga uuugga c
  ||||||| | ||||   |||||||  |||||| ||||||  
  cucguAG G GACU   GGUUUUU  AGGUuu aggcuu a
aa       - -    --A       --      u      u 

Annotation confidence Not enough data

Genome context

chr1: 18897071-18897148 [-]

Disease association

hsa-mir-1290 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1290

• Accession: MIMAT0005880
• Description: Homo sapiens hsa-miR-1290 mature miRNA
• Sequence: 53 - UGGAUUUUUGGAUCAGGGA - 71
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 18285502
   Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
   "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
   "Genome Res (2008) 18:610-621