Accession
MI0006352
Symbol
HGNC:
MIR1290
Description
Homo sapiens
hsa-mir-1290 precursor miRNA mir-1290
Gene
family?
family?
RF03650;
mir-1290
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR1290 is an exosomal miRNA that has been studied in various contexts. In the context of colorectal adenoma (CRA), MIR1290 levels were found to be a significant discriminating factor in identifying CRA in patients [PMC8116025]. In the context of non-alcoholic fatty liver disease (NAFLD), a miRNA panel that included MIR1290 showed high diagnostic accuracy [PMC5910543]. In melanoma cells, MIR1290 was found to be downregulated by POL treatment, and its downregulation promoted melanoma-cell autophagy by regulating the expression of BECN1 [PMC5604572]. MIR1290 levels were also found to be increased in primary melanoma tissues compared to adjacent normal tissues [PMC5604572]. Additionally, MIR1290 has been studied in the context of HIV-1 replication and as a potential marker for early diagnosis of necrotizing enterocolitis (NEC) [PMC9237370] [PMC9523100]. Furthermore, MIR1290 has been implicated in muscle atrophy and as a potential circulating biomarker for pancreatic cancer diagnosis [PMC7958887] [PMC6219528]. The role of MIR1290 in melanoma and ovarian cancer is still not well-studied compared to other tumors, but it has been shown to have oncogenic functions in other human tumors such as gastric cancer and esophageal squamous-cell carcinoma [PMC5604572] [PMC8928998]. The expression levels of MIR1290 have also been associated with SARS-CoV-2 infection and hypoxia-associated extracellular vesicles (EVs) in melanoma patients with poor prognosis. Additionally, it has been reported that combining the expression levels of MIR1290 with CA19-9 improves the effectiveness for selecting patients at risk for pancreatic ductal adenocarcinoma (PDAC) [PMC10057657] [PMC5465008].
Literature search
40 open access papers mention hsa-mir-1290
(195 sentences)
(195 sentences)
Sequence
270
reads,
373
reads per million, 30 experiments
gagcgucacguugacacucaaaaaguuucagauuuuggaacauuucggauuuUGGAUUUUUGGAUCAGGGAugcucaa
(((((((.(.((((...(((((((..((((((.((((((....)))))).))))))))))))).))))))))))))..
(((((((.(.((((...(((((((..((((((.((((((....)))))).))))))))))))).))))))))))))..
Structure
-- a g cac gu u a gagcguc c uuga ucaaaaa uucaga uuugga c ||||||| | |||| ||||||| |||||| |||||| cucguAG G GACU GGUUUUU AGGUuu aggcuu a aa - - --A -- u u
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr1: 18897071-18897148 [-]
Disease association
hsa-mir-1290 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-1290
| Accession | MIMAT0005880 |
| Description | Homo sapiens hsa-miR-1290 mature miRNA |
| Sequence | 53 - UGGAUUUUUGGAUCAGGGA - 71 |
| Evidence |
experimental
Illumina [1] |
| Database links |
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| Predicted targets |
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References
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