Accession
MI0006415
Symbol
HGNC:
MIR1275
Description
Homo sapiens
hsa-mir-1275 precursor miRNA
Gene family
MIPF0000674;
mir-1275
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR1275 is a functional microRNA coding gene that has been linked to coronary atherosclerosis [PMC7123062]. It has also been directly reported to participate in multiple sclerosis (MS) [PMC6871504]. In addition, probe cg03903398 targets MIR1275, making it an effective microRNA coding gene [PMC6871504'>PMC6871504]. MIR1275 is one of the four miRNAs that were found to be downregulated in a study on T1D patients, suggesting its involvement in immune regulation and beta cell function [PMC7989380]. Another meta-analysis of studies on T1D patients also identified MIR1275 as one of the miRNAs involved in immune regulation and insulin processing, suggesting its potential as a biomarker for T1D [PMC6768498]. Furthermore, MIR1275 has been found to be negatively correlated with mitochondrial membrane potential (MMP) suppression and associated genes [PMC8327461]. It has also been reported to be dysregulated in certain types of cancer and infection [PMC5865775]. Lastly, E6 stabilizes RACK1 through O-GlcNAcylation at Ser122 and inhibits MIR1275, which inhibits the LGALS1 gene that encodes galactin1, promoting tumor invasion and metastasis [PMC10006576]. References: - PMC7123062 - PMC6871504 - PMC7989380 - PMC6768498 - PMC8327461 - PMC5865775 - PMC10006576
Literature search
33 open access papers mention hsa-mir-1275
(58 sentences)
(58 sentences)
Sequence
6111
reads,
359
reads per million, 147 experiments
ccucugugagaaaggguGUGGGGGAGAGGCUGUCuugugucuguaaguaugccaaacuuauuuuccccaaggcagaggga
(((((((...........((((((((((((...((((......))))...))).......)))))))))..)))))))..
(((((((...........((((((((((((...((((......))))...))).......)))))))))..)))))))..
Structure
-- gagaaaggguG ------- UGU ug ccucugu UGGGGGAGA GGC Cuug u ||||||| ||||||||| ||| |||| ggagacg accccuuuu ccg gaau c ag ---------ga auucaaa uau gu
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr6: 33999972-34000051 [-]
Disease association
hsa-mir-1275 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-1275
| Accession | MIMAT0005929 |
| Description | Homo sapiens hsa-miR-1275 mature miRNA |
| Sequence | 18 - GUGGGGGAGAGGCUGUC - 34 |
| Evidence |
experimental
Illumina [1] |
| Database links |
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| Predicted targets |
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References
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