Stem-loop hsa-mir-1973

Accession

MI0009983

Symbol

HGNC: MIR1973

Description

Homo sapiens hsa-mir-1973 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR1973 is a microRNA that is involved in various biological processes. It has been found to be associated with the translocation associated membrane protein 1-like 1 (TRAM1L1) gene [PMC4852408]. The expression pattern of MIR1973 in alveolar type II (ATII) cells from emphysema patients and controls was similar to that of 16S rRNA, suggesting a direct link between MIR1973 and long non-coding RNAs (lncRNAs) [PMC9313339]. The levels of MIR1973 and miR4485-3p, which are partially derived from MT-RNR2 gene transcripts, were analyzed [PMC9313339]. Increased levels of MIR1973 were found in patients with chronic obstructive pulmonary disease (COPD) compared to smokers [PMC9313339]. In emphysema, the expression of MIR1973 was decreased in ATII cells compared to smokers and was lower in nonsmokers than in smokers [PMC9313339]. In a dataset analysis, MIR1973 was not represented [PMC7425458]. CpGs within 10,000 bp of a gene were identified, including two CpGs mapped to NLRC5 and MIR1973 within 1,500 bp of transcription start sites [PMC7425458]. Furthermore, the expression of MIR1973 has been shown to increase resistance in lung adenocarcinoma cells with subsequent low apoptosis intensity [PMC7425458].

Literature search

12 open access papers mention hsa-mir-1973
(17 sentences)

Sequence

390 reads, 73 reads per million, 55 experiments

uauguucaacggccaugguauccugACCGUGCAAAGGUAGCAUA
(((((((....((.(((((......)))))))....).))))))

Structure

      - aacg  c     au 
uauguu c    gc auggu  c
|||||| |    || |||||   
AUACGA G    CG UGCCA  c
      U GAAA  -     gu 

Annotation confidence Not enough data

Genome context

Unknown

Disease association

hsa-mir-1973 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1973

• Accession: MIMAT0009448
• Description: Homo sapiens hsa-miR-1973 mature miRNA
• Sequence: 26 - ACCGUGCAAAGGUAGCAUA - 44
• Evidence: experimental ; cloned [1]

References

1. PubMed ID: 18923441
   Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia
   "Schotte D, Chau JC, Sylvester G, Liu G, Chen C, van der Velden VH, Broekhuis MJ, Peters TC, Pieters R, den Boer ML"
   "Leukemia (2009) 23:313-322