Stem-loop hsa-mir-1973

Accession

MI0009983

Symbol

HGNC: MIR1973

Description

Homo sapiens hsa-mir-1973 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR1973 is a microRNA implicated in various respiratory conditions, including emphysema and chronic obstructive pulmonary disease (COPD) [PMC9313339]. It is associated with the translocation associated membrane protein 1-like 1 (TRAM1L1) gene and is partially transcribed from the MT-RNR2 gene [PMC4852408]. The expression of MIR1973 in alveolar type II (ATII) cells from emphysema patients mirrors that of 16S rRNA, suggesting a connection with long non-coding RNAs and MT-RNR2 transcripts [PMC9313339]. In plasma samples from COPD patients, MIR1973 levels were elevated in the early stages of the disease (GOLD1) compared to smokers, while its expression was reduced in ATII cells from emphysema patients relative to smokers and even lower in nonsmokers [PMC9313339]. However, MIR1973 was not detected in a certain dataset analysis [PMC7425458]. Epigenetic studies identified CpG sites near the MIR1973 gene that may influence its expression [PMC7425458]. In lung adenocarcinoma cells, increased expression of MIR1973 has been linked to resistance and reduced apoptosis intensity, indicating its potential role in cancer cell survival [PMC7425458].

Literature search

12 open access papers mention hsa-mir-1973
(17 sentences)

Sequence

390 reads, 73 reads per million, 55 experiments

uauguucaacggccaugguauccugACCGUGCAAAGGUAGCAUA
(((((((....((.(((((......)))))))....).))))))

Structure

      - aacg  c     au 
uauguu c    gc auggu  c
|||||| |    || |||||   
AUACGA G    CG UGCCA  c
      U GAAA  -     gu 

Annotation confidence Not enough data

Genome context

Unknown

Disease association

hsa-mir-1973 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1973

• Accession: MIMAT0009448
• Description: Homo sapiens hsa-miR-1973 mature miRNA
• Sequence: 26 - ACCGUGCAAAGGUAGCAUA - 44
• Evidence: experimental ; cloned [1]

References

1. PubMed ID: 18923441
   Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia
   "Schotte D, Chau JC, Sylvester G, Liu G, Chen C, van der Velden VH, Broekhuis MJ, Peters TC, Pieters R, den Boer ML"
   "Leukemia (2009) 23:313-322