Accession
MI0011285
Symbol
HGNC:
MIR2278
Description
Homo sapiens
hsa-mir-2278 precursor miRNA mir-2278
Gene
family?
family?
RF04166;
mir-2278
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR2278 is a microRNA whose upregulation has been linked to the suppression of leukemic cell growth and the promotion of apoptosis [PMC7277136]. This microRNA has not been previously associated with pancreatic cancer, marking a novel area of investigation [PMC7277136]. Bioinformatic analyses suggest that compounds such as sulforaphane, SF102, and SF134 may modulate NF-κB signaling pathways through the induction of MIR2278, which in turn could regulate a variety of NF-κB target genes [PMC7277136]. Among the miRNAs analyzed, MIR2278 stands out as it is predicted to influence the largest number of NF-κB-related genes [PMC7277136]. Furthermore, MIR2278 has been identified as significantly downregulated in response to treatments with sulforaphane and related compounds [PMC7277136]. This downregulation contrasts with findings in other studies where MIR2278 is among the most upregulated miRNAs under certain conditions [PMC4215582], suggesting context-dependent roles for this microRNA in cellular processes related to cancer.
Literature search
2 open access papers mention hsa-mir-2278
(2 sentences)
(2 sentences)
Sequence
466
reads,
25
reads per million, 52 experiments
gugcugcagguguugGAGAGCAGUGUGUGUUGCCUGGggacuguguggacugguaucacccagacagcuugcacugacuccagacccugccgucau
((((.(((((.(((((((..((((((..((((.(((((((((((....)).))..)).))))).))))..)))))).))))).))))))).).)))
((((.(((((.(((((((..((((((..((((.(((((((((((....)).))..)).))))).))))..)))))).))))).))))))).).)))
Structure
- u u - AG GU C - -- - g gug c gcagg gu ugGAG CAGUGU GUUG CUGGg ga cu gu u ||| | ||||| || ||||| |||||| |||| ||||| || || || uac g cgucc ca accuc gucacg cgac gaccc cu gg ca g u c - g -a uu a a au u g
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr9: 94809962-94810057 [+]
Disease association
hsa-mir-2278 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-2278
| Accession | MIMAT0011778 |
| Description | Homo sapiens hsa-miR-2278 mature miRNA |
| Sequence | 16 - GAGAGCAGUGUGUGUUGCCUGG - 37 |
| Evidence |
experimental
454 [1] |
| Database links |
|
| Predicted targets |
|
References
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