Stem-loop hsa-mir-2278

Accession

MI0011285

Symbol

HGNC: MIR2278

Description

Homo sapiens hsa-mir-2278 precursor miRNA mir-2278

Gene
family

RF04166; mir-2278

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

The only available information about MIR2278 and cancer is that its upregulation is associated with the inhibition of leukemic cell proliferation and enhanced apoptosis [PMC7277136]. Interestingly, our miRNA candidates MIR2278, miR27b-5p and miR29b-1-5p have never before been documented in pancreatic cancer, as far as we know [PMC7277136]. Our bioinformatic analysis of miRNA array data now predict that sulforaphane, SF102, and SF134 affect NF-κB signaling by the induction of MIR2278, which is involved in the regulation of many NF-κB target genes [PMC7277136]. The top candidate was MIR2278, because it was predicted to regulate the highest number of NF-κB-related target genes, followed by miR27b-5p and miR29b-1-5p, which partially overlapped in regulation of NF-κB-related target genes [PMC7277136]. By this method, we identified MIR2278 as common and most significantly downregulated miRNA following sulforaphane, SF102, and SF134 treatment (Table S1) [PMC7277136]. In a separate study, it was observed that MIR2278 was one of the most upregulated microRNAs [PMC4215582].

Literature search

2 open access papers mention hsa-mir-2278
(2 sentences)

Sequence

466 reads, 25 reads per million, 52 experiments

gugcugcagguguugGAGAGCAGUGUGUGUUGCCUGGggacuguguggacugguaucacccagacagcuugcacugacuccagacccugccgucau
((((.(((((.(((((((..((((((..((((.(((((((((((....)).))..)).))))).))))..)))))).))))).))))))).).)))

Structure

   - u     u  -     AG      GU    C     -  --  -  g 
gug c gcagg gu ugGAG  CAGUGU  GUUG CUGGg ga  cu gu u
||| | ||||| || |||||  ||||||  |||| ||||| ||  || ||  
uac g cgucc ca accuc  gucacg  cgac gaccc cu  gg ca g
   u c     -  g     -a      uu    a     a  au  u  g 

Annotation confidence Not enough data

Genome context

chr9: 94809962-94810057 [+]

Disease association

hsa-mir-2278 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-2278

• Accession: MIMAT0011778
• Description: Homo sapiens hsa-miR-2278 mature miRNA
• Sequence: 16 - GAGAGCAGUGUGUGUUGCCUGG - 37
• Evidence: experimental ; 454 [1]

References

1. PubMed ID: 19508715
   Identification and analysis of miRNAs in human breast cancer and teratoma samples using deep sequencing
   Nygaard S, Jacobsen A, Lindow M, Eriksen J, Balslev E, Flyger H, Tolstrup N, Møller S, Krogh A, Litman T
   BMC Med Genomics (2009) 2:35