miRBase entry: hsa-mir-466

Stem-loop hsa-mir-466

Homo sapiens hsa-mir-466 precursor miRNA
Gene family
MIPF0000316; mir-467

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR466 is a miRNA that has been found to have five potential target genes that are differentially expressed in patients with age-related macular degeneration (AMD) compared to unaffected individuals [PMC5429617]. A previous study identified 17 new miRNAs, including MIR466, which belong to 11 miRNA families and can regulate 64 sorghum genes involved in various cellular processes [PMC5360763]. Among these processes are cell cycle regulation, metabolism, protein degradation, RNA processing, stress response, and transportation [PMC5360763]. MIR466 is also involved in the regulation of matrix metalloproteinase-9 (MMP9) expression and can downregulate its expression by binding to the 3' UTR region of MMP9 [PMC4568920]. Inhibition of MIR466 has been achieved using a specific inhibitor (AM18443) in endothelial cells (ECs), along with other miRNA inhibitors [PMC9307898]. Additionally, MIR466 has been shown to regulate expression of MMP9 in diabetic heart tissue and promote proliferation of ECs and formation of capillary-like structures [PMC8355361]. Overall, these findings highlight the importance of MIR466 in various biological processes and its potential as a therapeutic target for diseases such as AMD and diabetes-related heart damage.

Literature search
18 open access papers mention hsa-mir-466
(46 sentences)


55 reads, 26 reads per million, 22 experiments

                     a       a        uau 
guguguguauauguguguugc ugugugu uaugugug   a
||||||||||||||||||||| ||||||| ||||||||    
cguacauauaUACACACAACG ACAUACA AUAcacau   u
                     C       C        gua 

Annotation confidence Not enough data
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Genome context
chr3: 31161704-31161787 [-]

Disease association
hsa-mir-466 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-466

Accession MIMAT0015002
Description Homo sapiens hsa-miR-466 mature miRNA
Evidence experimental
Illumina [1-2]
Database links
Predicted targets


  1. PubMed ID: 20300190
    Characterization of the Melanoma miRNAome by Deep Sequencing
    "Stark MS, Tyagi S, Nancarrow DJ, Boyle GM, Cook AL, Whiteman DC, Parsons PG, Schmidt C, Sturm RA, Hayward NK"
    "PLoS One (2010) 5:e9685

  2. PubMed ID: 21199797
    Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene
    "Persson H, Kvist A, Rego N, Staaf J, Vallon-Christersson J, Luts L, Loman N, Jonsson G, Naya H, Hoglund M, Borg A, Rovira C"
    "Cancer Res (2011) 71:78-86