Stem-loop hsa-mir-378c

Accession

MI0015825

Symbol

HGNC: MIR378C

Description

Homo sapiens hsa-mir-378c precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR378C is a microRNA that has been implicated in various biological processes and diseases, including sepsis and cancer [PMC8358855; PMC8017737].'>PMC8017737].. In sepsis, MIR378C is among the plasma miRNAs that are significantly elevated in patients with community-acquired pneumonia (CAP), suggesting its potential role in the host response to infection [PMC8358855]. In the context of cancer, particularly gastric cancer, MIR378C expression is low, which has been associated with its potential as a diagnostic and prognostic biomarker [PMC8017737]. Notably, MIR378C has been identified as an independent prognostic factor for gastric cancer patients when considering differentiation and TNM staging [PMC8017737]. This finding underscores the significance of MIR378C in clinical outcomes and its potential utility in patient prognosis [PMC8017737].

Literature search

193 open access papers mention hsa-mir-378c
(913 sentences)

Sequence

1122138 reads, 4181 reads per million, 126 experiments

ggaggccaucACUGGACUUGGAGUCAGAAGAGUGGagucgggucagacuucaacucugacuuugaagguggugagugccuc
.(((((..((((((...(((((((((((....(((((((......)))))))..)))))))))))...))))))..)))))

Structure

g     ca      GAC           AGAG       gg 
 gaggc  ucACUG   UUGGAGUCAGA    UGGaguc  g
 |||||  ||||||   |||||||||||    |||||||   
 cuccg  aguggu   aguuucagucu    acuucag  u
-     ug      gga           --ca       ac 

Annotation confidence Not enough data

Genome context

chr10: 130962588-130962668 [-]

Disease association

hsa-mir-378c is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-378c

• Accession: MIMAT0016847
• Description: Homo sapiens hsa-miR-378c mature miRNA
• Sequence: 11 - ACUGGACUUGGAGUCAGAAGAGUGG - 35
• Evidence: experimental ; SOLiD [1]

References

1. PubMed ID: 19784364
   Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors
   Goff LA, Davila J, Swerdel MR, Moore JC, Cohen RI, Wu H, Sun YE, Hart RP
   PLoS One (2009) 4:e7192